Document Detail

The MHC influences acute graft versus host disease in MHC matched adults undergoing allogeneic bone marrow transplantation.
MedLine Citation:
PMID:  8275034     Owner:  NLM     Status:  MEDLINE    
To determine whether the MHC plays an antigen non-specific role in the development of acute GVHD, the prevalence of acute GVHD in relation to MHC genotype was examined in 51 adult patients undergoing allogeneic BM grafting. The majority of patients received grafts from HLA-identical siblings. HLA-B7 haplotypes were associated with a decreased risk of acute GVHD (2 of 15, p = 0.005) whereas HLA-B44 haplotypes were associated with a higher risk of acute GVHD (11 of 14, p = 0.02). As these alleles have been reported previously as having opposite effects in relation to inflammatory mediators, these findings may have important implications with respect to donor selection and patient management.
L A Smyth; C S Witt; F T Christiansen; R P Herrmann; P N Hollingsworth; D C Townend; E Edward; R L Dawkins
Related Documents :
17249214 - Serum adenosine deaminase and arylsulphatase a as an index of early infiltration of cen...
2772794 - Splenectomy for massive splenomegaly.
6378004 - Treatment of intestinal cryptosporidiosis with spiramycin.
19422784 - Proteomics-based prediction of clinical response in acute myeloid leukemia.
3500504 - Expression of major histocompatibility complex class ii subregion products by jejunal e...
22026424 - Chinese head trauma data bank: effect of hyperthermia on the outcome of acute head trau...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  12     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-02-07     Completed Date:  1994-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  351-5     Citation Subset:  IM    
Department of Clinical Immunology, Royal Perth Hospital, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Bone Marrow Transplantation / immunology*
Graft vs Host Disease / epidemiology,  genetics*,  immunology
HLA Antigens / genetics,  immunology*
HLA-B Antigens / genetics,  immunology
HLA-B7 Antigen / genetics,  immunology
Major Histocompatibility Complex*
Reg. No./Substance:
0/HLA Antigens; 0/HLA-B Antigens; 0/HLA-B44; 0/HLA-B7 Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Factors affecting hair regrowth after bone marrow transplantation.
Next Document:  Intravenous pentoxifylline failed to prevent transplant-related toxicities in allogeneic bone marrow...