Document Detail


The MHC influences acute graft versus host disease in MHC matched adults undergoing allogeneic bone marrow transplantation.
MedLine Citation:
PMID:  8275034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine whether the MHC plays an antigen non-specific role in the development of acute GVHD, the prevalence of acute GVHD in relation to MHC genotype was examined in 51 adult patients undergoing allogeneic BM grafting. The majority of patients received grafts from HLA-identical siblings. HLA-B7 haplotypes were associated with a decreased risk of acute GVHD (2 of 15, p = 0.005) whereas HLA-B44 haplotypes were associated with a higher risk of acute GVHD (11 of 14, p = 0.02). As these alleles have been reported previously as having opposite effects in relation to inflammatory mediators, these findings may have important implications with respect to donor selection and patient management.
Authors:
L A Smyth; C S Witt; F T Christiansen; R P Herrmann; P N Hollingsworth; D C Townend; E Edward; R L Dawkins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  12     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-02-07     Completed Date:  1994-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  351-5     Citation Subset:  IM    
Affiliation:
Department of Clinical Immunology, Royal Perth Hospital, Australia.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Alleles
Bone Marrow Transplantation / immunology*
Graft vs Host Disease / epidemiology,  genetics*,  immunology
HLA Antigens / genetics,  immunology*
HLA-B Antigens / genetics,  immunology
HLA-B7 Antigen / genetics,  immunology
Haplotypes
Histocompatibility
Humans
Major Histocompatibility Complex*
Prevalence
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/HLA-B Antigens; 0/HLA-B44; 0/HLA-B7 Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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