Document Detail

MHC-dependent mate choice in humans: why genomic patterns from the HapMap European American dataset support the hypothesis.
MedLine Citation:
PMID:  22344965     Owner:  NLM     Status:  MEDLINE    
The role of the major histocompatibility complex (MHC) in mate choice in humans is controversial. Nowadays, the availability of genetic variation data at genomic scales allows for a careful assessment of this question. In 2008, Chaix et al. reported evidence for MHC-dependent mate choice among European American spouses from the HapMap 2 dataset. Recently, Derti et al. suggested that this observation was not robust. Furthermore, when Derti et al. applied similar analyses to the HapMap 3 European American samples, they did not see a significant effect. Although some of the points raised by Derti et al. are relevant, we disagree with the reported absence of evidence for MHC-dependent mate choice within the HapMap samples. More precisely, we show here that the MHC dissimilarity among HapMap 3 European American spouses is still extreme in comparison to the rest of the genome, even after multiple testing correction. This finding supports the hypothesis of MHC-dependent mate choice in some human populations.
Romain Laurent; Raphaëlle Chaix
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Publication Detail:
Type:  Journal Article     Date:  2012-02-16
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  34     ISSN:  1521-1878     ISO Abbreviation:  Bioessays     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-14     Completed Date:  2012-07-16     Revised Date:  2012-08-09    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 WILEY Periodicals, Inc.
Eco-Anthropologie et Ethnobiologie, UMR 7206 CNRS, MNHN, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
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MeSH Terms
Choice Behavior
European Continental Ancestry Group
Genome, Human / genetics*
HapMap Project*
Major Histocompatibility Complex / genetics*
Sexual Partners
Comment In:
Bioessays. 2012 Jul;34(7):576-7   [PMID:  22467222 ]

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