| MHC class II molecules in tumour immunology: prognostic marker and target for immune modulation. | |
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MedLine Citation:
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PMID: 16920500 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MHC class II molecules presenting MHC class II restricted antigens play an important role in the activation of CD4+ T cells, which are the central orchestrating cells of an immune response. This review focuses on the particular role of MHC class II molecules in tumour immunology. The MHC class II antigen presentation pathway and the expression of MHC class II molecules on tumour cells related to clinical outcome is discussed. Improving the MHC class II tumour antigen presentation pathway, for instance by downregulation of the invariant chain or modulation of HLA-DO expression, offers many opportunities for developing new modalities of immunotherapy. |
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Authors:
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M E D Chamuleau; G J Ossenkoppele; A A van de Loosdrecht |
Publication Detail:
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Type: Journal Article; Review Date: 2006-07-07 |
Journal Detail:
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Title: Immunobiology Volume: 211 ISSN: 0171-2985 ISO Abbreviation: Immunobiology Publication Date: 2006 |
Date Detail:
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Created Date: 2006-08-21 Completed Date: 2006-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8002742 Medline TA: Immunobiology Country: Germany |
Other Details:
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Languages: eng Pagination: 619-25 Citation Subset: IM |
Affiliation:
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Department of Haematology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. m.chamuleau@vumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Histocompatibility Antigens Class II / metabolism* Humans Immunologic Factors / metabolism* Neoplasms / diagnosis, immunology*, metabolism Prognosis Tumor Markers, Biological / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Histocompatibility Antigens Class II; 0/Immunologic Factors; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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