Document Detail


MHC class II alleles and haplotypes in patients with pemphigus vulgaris from India.
MedLine Citation:
PMID:  9008309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pemphigus vulgaris (PV) is a blistering disease of the skin and mucous membranes characterized by an autoantibody response against a keratinocyte adhesion molecule, desmoglein 3, causing acantholysis and blister formation. We compared high resolution MHC class II alleles and haplotype frequencies (HLA-DRB, DQA1 and DQB1) in 37 patients with PV to 89 haplotypes of normal relatives from New Delhi and Ahmedabad. We found that PV patients had significantly increased frequencies of DRB1*1404 (P < 0.0001), DQA1*0101 (P = 0.001), and DQB1*0503 (P < 0.0001). These associations were due to the increased frequencies of the haplotype HLA-DRB1*1404, DRB3*0202, DQA1*0101, DQB1*0503 in patients compared to control haplotypes (p < 0.0001). Also, patients from Ahmedabad had a significant increase in HLA-DQB1*0302 (p = 0.03). An identical amino acid sequence (Leu-Leu-Glu-Arg-Arg-Arg-Ala-Glu), in positions 67-74 of the beta domain of DRB alleles is restricted to some DR14 alleles. Therefore, there are three possible explanations for class II allele involvement in autoantibody in PV patients with class II haplotypes marked by HLA-DR14. First, the class II alleles could be markers for an unidentified susceptibility gene in linkage disequilibrium with them. Second, the primary association could be with DQB1*0503 and the association with HLA-DR14 alleles would be the result of linkage disequilibrium. Third, the HLA-DRB1 locus susceptibility could involve a specific amino acid sequence in the third hypervariable region shared by several HLA-DR14 alleles.
Authors:
J C Delgado; D E Yunis; M V Bozón; M Salazar; R Deulofeut; D Turbay; N K Mehra; J S Pasricha; R S Raval; H Patel; B K Shah; K Bhol; C A Alper; A R Ahmed; E J Yunis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Tissue antigens     Volume:  48     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-25     Completed Date:  1997-03-25     Revised Date:  2010-10-15    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  668-72     Citation Subset:  IM    
Affiliation:
Division of Immunogenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
Alleles*
Gene Frequency
Genes, MHC Class II*
HLA-DQ Antigens / classification,  genetics
HLA-DR Antigens / classification,  genetics
Haplotypes
Humans
India
Pemphigus / immunology*
Grant Support
ID/Acronym/Agency:
DE09978/DE/NIDCR NIH HHS; EY08379/EY/NEI NIH HHS; HL29583/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/HLA-DQ Antigens; 0/HLA-DQA1; 0/HLA-DQB1 antigen; 0/HLA-DR Antigens; 0/HLA-DRB3; 0/HLA-DRB4; 0/HLA-DRB5; 128338-86-3/HLA-DRB1 antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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