| METRADISC-XL: A program for meta-analysis of multidimensional ranked discovery oriented datasets including microarrays. | |
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MedLine Citation:
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PMID: 22959629 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A comprehensive software for performing meta-analysis of ranked discovery oriented datasets, such as those derived from microarrays or other high throughput technologies, and for testing between-study heterogeneity for biological variables (gene expression, microRNA, proteomic, or other high-dimensional data) is presented. The software can identify biological probes that have either very high average ranks (e.g. consistently over-expressed genes) or very low average ranks (e.g. consistently under-expressed genes). The program tests each probe's average rank and the between-study heterogeneity of the study-specific ranks. Furthermore, it performs heterogeneity analyses restricted to probes with similar average ranks. The program allows both unweighted and weighted analysis. Statistical inferences are based on Monte Carlo permutation tests. |
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Authors:
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Elias Zintzaras; John P A Ioannidis |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-4 |
Journal Detail:
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Title: Computer methods and programs in biomedicine Volume: - ISSN: 1872-7565 ISO Abbreviation: Comput Methods Programs Biomed Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8506513 Medline TA: Comput Methods Programs Biomed Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece; Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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