| MEL1S, not MEL1, is overexpressed in myelodysplastic syndromes patients with t(1;3)(p36;q21). | |
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MedLine Citation:
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PMID: 16102824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Balanced chromosomal translocations rarely occur in myelodysplastic syndromes (MDS). We describe here in three further Chinese patients with myelodysplastic syndromes (MDS) whose cytogenetic analysis showed t(1;3)(p36;q21). We detected the expression pattern of MEL1 and MEL1s in BM of two healthy subjects and the three patients, and found that the expression of MEL1s was overexpressed in MDS patients with t(1;3)(p36;q21). Our findings combined previous observations reported in literature support that MDS patients with t(1;3)(p36;q21) should be a new specific subset of MDS. Imbalance of a complete MEL1 message with a PR domain and a short MEL1 message lacking a PR domain (MEL1S) might be involved in the pathogenesis of these patients. |
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Authors:
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Zhijian Xiao; Meirong Zhang; Xuping Liu; Yue Zhang; Lin Yang; Yushu Hao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-08-15 |
Journal Detail:
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Title: Leukemia research Volume: 30 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-01-10 Completed Date: 2006-03-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 332-4 Citation Subset: IM |
Affiliation:
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Department of Clinical Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, PR China. zjxiao@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chromosomes, Human, Pair 1 / genetics* Chromosomes, Human, Pair 3 / genetics* DNA-Binding Proteins / biosynthesis*, genetics Female Gene Expression Regulation* Humans Male Middle Aged Myelodysplastic Syndromes / genetics, metabolism*, pathology Protein Structure, Tertiary / genetics RNA, Messenger / biosynthesis, genetics Sequence Deletion / genetics Transcription Factors / biosynthesis*, genetics Translocation, Genetic / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/PRDM16 protein, human; 0/RNA, Messenger; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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