Document Detail


MEKing Retinoids Work Better.
MedLine Citation:
PMID:  20708151     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Retinoids can induce terminal differentiation in a subset of neuronal cancer cells, but what determines response has been unclear. In a recent issue of Cell, Hölzel and colleagues show that hyperactive RAS signaling imparts retinoid resistance to neuroblastoma cells, which can be reversed by inhibiting MAPK, suggesting new therapeutic opportunities.
Authors:
Yaël P Mossé; John M Maris
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Cancer cell     Volume:  18     ISSN:  1878-3686     ISO Abbreviation:  -     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-8-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130617     Medline TA:  Cancer Cell     Country:  -    
Other Details:
Languages:  ENG     Pagination:  103-105     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, University of Pennsylvania School of Medicine, and the Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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