| MEKing Retinoids Work Better. | |
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MedLine Citation:
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PMID: 20708151 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Retinoids can induce terminal differentiation in a subset of neuronal cancer cells, but what determines response has been unclear. In a recent issue of Cell, Hölzel and colleagues show that hyperactive RAS signaling imparts retinoid resistance to neuroblastoma cells, which can be reversed by inhibiting MAPK, suggesting new therapeutic opportunities. |
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Authors:
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Yaël P Mossé; John M Maris |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Cancer cell Volume: 18 ISSN: 1878-3686 ISO Abbreviation: - Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-8-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130617 Medline TA: Cancer Cell Country: - |
Other Details:
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Languages: ENG Pagination: 103-105 Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, University of Pennsylvania School of Medicine, and the Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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