Document Detail

MEK Inhibition in BRAF-Mutated Melanoma.
MedLine Citation:
PMID:  23034029     Owner:  NLM     Status:  In-Data-Review    
To the Editor: Although the efficacy of serine-threonine protein kinase (BRAF) inhibitors has been shown in patients with advanced melanoma who have the V600E BRAF mutation,(1),(2) data on the population with the V600K BRAF mutation are more limited and less encouraging. A phase 2 trial of vemurafenib showed a partial response in 4 of 10 patients with V600K BRAF mutations but provided no data on progression-free survival among these patients.(3) In the BREAK-2 (BRAF Inhibitor V600 E and K Metastatic Melanoma Phase 2) study of dabrafenib, the overall response rate and median progression-free survival were lower among 16 patients . . .
Alex Mackenzie; Kym Boycott
Related Documents :
17224759 - A clinical and molecular genetic study of egyptian and saudi arabian patients with prim...
23586019 - Tnnt2 gene polymorphisms are associated with susceptibility to idiopathic dilated cardi...
23440719 - Ltbp4 genotype predicts age of ambulatory loss in duchenne muscular dystrophy.
23554779 - The susceptibility of t5-tg12 of the cftr gene in chronic bronchitis occurrence in a ch...
23323139 - Association between the g252a tumor necrosis factor-β gene polymorphism and medication...
23047739 - An atypical dent's disease phenotype caused by co-inheritance of mutations at clcn5 and...
20978139 - Adaptive selection of an incretin gene in eurasian populations.
10777009 - K-ras mutations, rectal crypt cells proliferation, and meat consumption in patients wit...
12676089 - Local regulation of homeostasis favors chromosomal instability.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  367     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1364-5     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  MEK Inhibition in BRAF-Mutated Melanoma.
Next Document:  Early surgery for infective endocarditis.