| MEK Inhibition in BRAF-Mutated Melanoma. | |
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MedLine Citation:
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PMID: 23034029 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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To the Editor: Although the efficacy of serine-threonine protein kinase (BRAF) inhibitors has been shown in patients with advanced melanoma who have the V600E BRAF mutation,(1),(2) data on the population with the V600K BRAF mutation are more limited and less encouraging. A phase 2 trial of vemurafenib showed a partial response in 4 of 10 patients with V600K BRAF mutations but provided no data on progression-free survival among these patients.(3) In the BREAK-2 (BRAF Inhibitor V600 E and K Metastatic Melanoma Phase 2) study of dabrafenib, the overall response rate and median progression-free survival were lower among 16 patients . . . |
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Authors:
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Alex Mackenzie; Kym Boycott |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The New England journal of medicine Volume: 367 ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: United States |
Other Details:
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Languages: eng Pagination: 1364-5 Citation Subset: AIM; IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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