Document Detail

MEK Inhibition in BRAF-Mutated Melanoma.
MedLine Citation:
PMID:  23034028     Owner:  NLM     Status:  In-Data-Review    
To the Editor: Although the efficacy of serine-threonine protein kinase (BRAF) inhibitors has been shown in patients with advanced melanoma who have the V600E BRAF mutation,(1),(2) data on the population with the V600K BRAF mutation are more limited and less encouraging. A phase 2 trial of vemurafenib showed a partial response in 4 of 10 patients with V600K BRAF mutations but provided no data on progression-free survival among these patients.(3) In the BREAK-2 (BRAF Inhibitor V600 E and K Metastatic Melanoma Phase 2) study of dabrafenib, the overall response rate and median progression-free survival were lower among 16 patients . . .
Paolo A Ascierto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  367     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1364-5     Citation Subset:  AIM; IM    
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