Document Detail

MEGX (monoethylglycinexylidide): a novel in vivo test to measure early hepatic dysfunction after hypovolemic shock.
MedLine Citation:
PMID:  7850580     Owner:  NLM     Status:  MEDLINE    
A quantitative liver test based on the formation of the lidocaine metabolite monoethylglycinexylidide (MEGX), was used to evaluate the effect of hemorrhagic shock at 40 mmHg for 90 min on Sprague-Dawley rats. After 2 h of stabilization, lidocaine was injected (2 mg/kg). A second group received volume resuscitation with Ringer's lactate over 1 h (15 mL/kg) after shock, and after 1 h of stabilization lidocaine was administered. These groups were compared to control animals. Blood samples were drawn at 0 time (baseline), prior to lidocaine injection, and at 10, 15, 30, and 60 min after lidocaine injection. MEGX values in shocked animals were significantly lower than in the control group; in animals receiving volume resuscitation, levels were higher than the shocked animals without resuscitation, but did not reach control levels. Thus, shock produced a significant depression of hepatocyte function, which was partially reversed by Ringer's lactate resuscitation. The MEGX test appears to be a suitable tool for clinical evaluation and therapeutic intervention after shock.
B Chandel; M J Shapiro; M Kurtz; W U Rana; M Matthews; M Jellinek; A E Baue
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  3     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-03-16     Completed Date:  1995-03-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-3; discussion 54-5     Citation Subset:  IM    
Department of Surgery, St. Louis University Health Sciences Center, Missouri 63104.
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MeSH Terms
Ischemia / blood
Lidocaine / analogs & derivatives*,  blood,  diagnostic use*,  pharmacokinetics
Liver / blood supply
Liver Function Tests*
Microsomes, Liver / metabolism
Predictive Value of Tests
Rats, Sprague-Dawley
Shock / blood,  physiopathology*
Reg. No./Substance:
137-58-6/Lidocaine; 7728-40-7/monoethylglycinexylidide

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