| MEGX (monoethylglycinexylidide): a novel in vivo test to measure early hepatic dysfunction after hypovolemic shock. | |
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MedLine Citation:
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PMID: 7850580 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A quantitative liver test based on the formation of the lidocaine metabolite monoethylglycinexylidide (MEGX), was used to evaluate the effect of hemorrhagic shock at 40 mmHg for 90 min on Sprague-Dawley rats. After 2 h of stabilization, lidocaine was injected (2 mg/kg). A second group received volume resuscitation with Ringer's lactate over 1 h (15 mL/kg) after shock, and after 1 h of stabilization lidocaine was administered. These groups were compared to control animals. Blood samples were drawn at 0 time (baseline), prior to lidocaine injection, and at 10, 15, 30, and 60 min after lidocaine injection. MEGX values in shocked animals were significantly lower than in the control group; in animals receiving volume resuscitation, levels were higher than the shocked animals without resuscitation, but did not reach control levels. Thus, shock produced a significant depression of hepatocyte function, which was partially reversed by Ringer's lactate resuscitation. The MEGX test appears to be a suitable tool for clinical evaluation and therapeutic intervention after shock. |
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Authors:
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B Chandel; M J Shapiro; M Kurtz; W U Rana; M Matthews; M Jellinek; A E Baue |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: 3 ISSN: 1073-2322 ISO Abbreviation: Shock Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-03-16 Completed Date: 1995-03-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 51-3; discussion 54-5 Citation Subset: IM |
Affiliation:
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Department of Surgery, St. Louis University Health Sciences Center, Missouri 63104. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotransformation Ischemia / blood Lidocaine / analogs & derivatives*, blood, diagnostic use*, pharmacokinetics Liver / blood supply Liver Function Tests* Male Microsomes, Liver / metabolism Predictive Value of Tests Rats Rats, Sprague-Dawley Shock / blood, physiopathology* |
| Chemical | |
Reg. No./Substance:
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137-58-6/Lidocaine; 7728-40-7/monoethylglycinexylidide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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