Document Detail


ME3221, a surmountable angiotensin AT1-receptor antagonist, prevents hypertensive complications in aged stroke-prone spontaneously hypertensive rats.
MedLine Citation:
PMID:  8791170     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The protective effects of ME3221, 3-methoxy-2,6-dimethyl-4-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-y l]methoxy] pyridine, on aged (32-week-old) stroke-prone spontaneously hypertensive rats (SHRSP) were studied following long-term (for 8 months) oral administration. At a dose of 10 mg/kg/day, ME3221 suppressed the mortality and the hypertensive complications observed in control SHRSP: cerebral apoplexy (hemorrhage, and spongeform and malacia in the cerebral cortex), increased proteinuria, and total N-acetyl-beta-D-glucosaminidase activity, and cardiac hypertrophy and pleural effusion. The protective activity of ME3221, a surmountable angiotensin AT1-receptor antagonist, was comparable to losartan, an insurmountable AT1-antagonist, and also to enalapril, an angiotensin-converting enzyme inhibitor. In addition, ME3221 reduced the systolic blood pressure more effectively than the two reference drugs.
Authors:
J Nagura; C Hui; M Yamamoto; S Yasuda; M Abe; M Hachisu; F Konno
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  71     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-03-21     Completed Date:  1997-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  39-49     Citation Subset:  IM    
Affiliation:
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / therapeutic use
Biphenyl Compounds / therapeutic use*
Blood Pressure / drug effects
Brain / drug effects
Cerebrovascular Disorders / etiology,  prevention & control
Enalapril / therapeutic use
Heart / drug effects
Hypertension / complications,  drug therapy*
Imidazoles / therapeutic use
Kidney / drug effects,  pathology
Losartan
Male
Myocardium / pathology
Rats
Rats, Inbred SHR
Receptors, Angiotensin / antagonists & inhibitors*
Tetrazoles / therapeutic use*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Biphenyl Compounds; 0/Imidazoles; 0/ME 3221; 0/Receptors, Angiotensin; 0/Tetrazoles; 114798-26-4/Losartan; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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