Document Detail


MDR1 in Paroxetine-Induced Sexual Dysfunction.
MedLine Citation:
PMID:  23152970     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001).
Authors:
Alexandra Zourková; Ondřej Slanař; Jiří Jarkovský; Ivana Palčíková; Eva Pindurová; Michaela Cvanová
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of sex & marital therapy     Volume:  39     ISSN:  1521-0715     ISO Abbreviation:  J Sex Marital Ther     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502387     Medline TA:  J Sex Marital Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  71-8     Citation Subset:  IM    
Affiliation:
a Central European Institute of Technology , Masaryk University , Brno , Czech Republic.
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