| MDR1 in Paroxetine-Induced Sexual Dysfunction. | |
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MedLine Citation:
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PMID: 23152970 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001). |
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Authors:
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Alexandra Zourková; Ondřej Slanař; Jiří Jarkovský; Ivana Palčíková; Eva Pindurová; Michaela Cvanová |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of sex & marital therapy Volume: 39 ISSN: 1521-0715 ISO Abbreviation: J Sex Marital Ther Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502387 Medline TA: J Sex Marital Ther Country: England |
Other Details:
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Languages: eng Pagination: 71-8 Citation Subset: IM |
Affiliation:
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a Central European Institute of Technology , Masaryk University , Brno , Czech Republic. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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