Document Detail


MDMA administration to pregnant Sprague-Dawley rats results in its passage to the fetal compartment.
MedLine Citation:
PMID:  16905291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent investigations have demonstrated that prenatal 3,4-methylenedeoxymethamphetamine (MDMA; ecstasy) exposure in rats results in significant and persistent changes in the developing brain. However, no published pharmacokinetic studies exist demonstrating that MDMA administered during pregnancy passes to the fetal compartment. This leaves open the question whether MDMA is directly acting on the fetal brain to produce the observed changes in previous studies, or whether such effects are an indirect result of MDMA administration to the pregnant dam. Therefore, pregnant rats were administered a single dose of MDMA (15 mg/kg, subcutaneous) at embryonic day 14 (E14) and the levels of MDMA and its metabolite 3,4-methylenedioxyamphetamine (MDA) were quantified in maternal plasma, amniotic fluid, and fetal brain over 8 h by HPLC. The time course of MDMA and MDA metabolism was reliable and reproducible in all tissues. There was a strong correlation between fetal amniotic fluid and fetal brain suggesting that amniotic fluid could be used to reliably estimate fetal brain levels without directly utilizing fetal brain tissue. These data also provide a framework for subsequent in vitro cell culture studies using biologically relevant MDMA doses.
Authors:
Nicholas G Campbell; James B Koprich; Nicholas M Kanaan; Jack W Lipton
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-06-08
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  28     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-09-12     Completed Date:  2006-11-07     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  459-65     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Way ML 559, Cincinnati, OH 45267, United States.
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MeSH Terms
Descriptor/Qualifier:
3,4-Methylenedioxyamphetamine / pharmacokinetics
Amniotic Fluid / metabolism
Animals
Biotransformation
Brain / metabolism
Female
Fetus / metabolism*
Hallucinogens / pharmacokinetics*
N-Methyl-3,4-methylenedioxyamphetamine / pharmacokinetics*
Pregnancy
Pregnancy, Animal / metabolism*
Rats
Rats, Sprague-Dawley
Tissue Distribution
Uterus / metabolism
Grant Support
ID/Acronym/Agency:
DA017399/DA/NIDA NIH HHS; DA019267/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Hallucinogens; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine; 4764-17-4/3,4-Methylenedioxyamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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