Document Detail

MDM2 and CDK4 expression in carcinosarcoma of the esophagus: comparison with squamous cell carcinoma and review of the literature.
MedLine Citation:
PMID:  12565795     Owner:  NLM     Status:  MEDLINE    
Certain tumors of the esophagus that display both sarcomatous and carcinomatous features have long been recognized. The nomenclature, classification, and histogenesis remain controversial and the microscopic differential diagnosis from other esophageal malignancies can be challenging, particularly in small biopsies. In this paper, we review the literature of carcinosarcoma and present two cases of esophageal carcinosarcoma, describing their salient histologic, immunohistochemical, and ultrastructural features. Also, we assess the expression of MDM2 and CDK4 in the carcinomatous and sarcomatous compartments of our cases and we compare them with the expression of these oncogenes in selected cases of esophageal squamous cell carcinoma with prominent stromal reaction. In both of our cases, identification of some epithelial ultrastructural and immunohistochemical features in cells of otherwise sarcomatous phenotype lends support to the common epithelial origin of these neoplasms. Moreover, positive staining for MDM2 and CDK4 in our cases with equally strong reactions in both carcinomatous and sarcomatous elements provides evidence of a role for these molecules in the pathogenesis of carcinosarcoma. In contrast, in cases of squamous cell carcinoma with prominent stromal reaction only the epithelial cells stained strongly for MDM2 and CDK4. These differences in the MDM2 and CDK4 immunohistochemical profile between carcinosarcomas and carcinomas of the esophagus may assist in their differential diagnosis.
Nikolaos G Nikitakis; Cinthia B Drachenberg; John C Papadimitriou
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Experimental and molecular pathology     Volume:  73     ISSN:  0014-4800     ISO Abbreviation:  Exp. Mol. Pathol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-02-05     Completed Date:  2003-02-27     Revised Date:  2012-06-25    
Medline Journal Info:
Nlm Unique ID:  0370711     Medline TA:  Exp Mol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  198-208     Citation Subset:  IM    
Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, Maryland 21201-1586, USA.
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MeSH Terms
Carcinoma, Squamous Cell / metabolism*,  pathology,  ultrastructure
Carcinosarcoma / metabolism*,  pathology,  ultrastructure
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinases / metabolism*
Esophageal Neoplasms / metabolism*,  pathology,  ultrastructure
Keratins / metabolism
Middle Aged
Neoplasm Proteins / metabolism
Nuclear Proteins / metabolism*
Proto-Oncogene Proteins / metabolism*
Proto-Oncogene Proteins c-mdm2
Reg. No./Substance:
0/Neoplasm Proteins; 0/Nuclear Proteins; 0/Proto-Oncogene Proteins; 68238-35-7/Keratins; EC protein, human; EC Kinase 4; EC Kinases; EC protein, human; EC Proteins c-mdm2

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