| MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study. | |
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MedLine Citation:
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PMID: 19850519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monocarboxylate Transporter 1 (MCT1) mediates the transport of the main fraction of lactate across the sarcolemma. A common polymorphic MCT1 variant has been identified, but its role in high intensity exercise performance has not been defined. We investigated the influence of MCT1 A1470T polymorphism (rs1049434) on lactate accumulation after high intensity circuit training. Ten men aged 20-26 performed three controlled circuit training (CWT) sessions at 60%, 70%, and 80% of the 15 repetition maximum (15RM), in non-consecutive days. CWT included three sets of a circuit of eight exercises, obtaining lactate measurements immediately after each set had been completed. Two independent variables were analysed: MTC1 genotypes according to the presence or absence of the A1470T polymorphism, and the intensity of circuit training. Genotype distributions were in Hardy-Weinberg equilibrium, being 30% wild-type, 50% heterozygotes, and 20% mutated homozygotes. Mean lactate concentration at 80% of 15RM were significantly higher than the mean lactate values at the other intensities (p<0.01). Significant differences between genetic groups were found in the lactate accumulation slope at 80% of 15RM (p=0.02) and in the maximal lactate concentration reached by all subjects in the study (L(max)) (p=0.03). The carriers of the A1470T polymorphism in the MTC1 gene seem to exhibit a worse lactate transport capability into the less active muscle cells for oxidation. |
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Authors:
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Rocío Cupeiro; Pedro J Benito; Nicola Maffulli; F Javier Calderón; Domingo González-Lamuño |
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Publication Detail:
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Type: Journal Article Date: 2009-10-22 |
Journal Detail:
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Title: Journal of science and medicine in sport / Sports Medicine Australia Volume: 13 ISSN: 1878-1861 ISO Abbreviation: J Sci Med Sport Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812598 Medline TA: J Sci Med Sport Country: Australia |
Other Details:
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Languages: eng Pagination: 526-30 Citation Subset: IM |
Affiliation:
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Laboratory of Exercise Physiology, Department of Health and Human Performance, Universidad Politecnica de Madrid, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Genotype Humans Lactic Acid / metabolism* Male Monocarboxylic Acid Transporters / genetics* Physical Endurance / genetics*, physiology Pilot Projects Polymorphism, Single Nucleotide* Symporters / genetics* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Monocarboxylic Acid Transporters; 0/Symporters; 0/monocarboxylate transport protein 1; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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