| MCP-3/CCL7 production by astrocytes: implications for SIV neuroinvasion and AIDS encephalitis. | |
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MedLine Citation:
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PMID: 21279498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monocyte/macrophages and activated lymphocytes traffic through normal brain, and this trafficking is increased in inflammatory conditions such as HIV encephalitis (HIVE). HIVE is characterized in part by perivascular accumulations of macrophages. The earliest events in this process are poorly understood and difficult or impossible to address in humans. The SIV-infected macaque model of neuroAIDS has demonstrated migration of monocytes into the brain early in disease, coincident with peak SIV viremia. The chemotactic signals that initiate the increased emigration of mononuclear cells into the CNS have not been described. Here, we describe astrocytes as a primary source of chemokines to facilitate basal levels of monocyte trafficking to CNS and that increased chemokine (C-C motif) ligand 7 (CCL7) production may be responsible for initiating the increased trafficking in neuroAIDS. We have previously published complementary in vivo work demonstrating the presence of monocyte chemoattractant protein 3 (MCP-3)/CCL7 within the brain of SIV-infected macaques. Here, we demonstrate that MCP-3/CCL7 is a significant chemokine produced by astrocytes, that basal monocyte migration may be facilitated by astrocyte-derived CCL7, that production of CCL7 is rapidly increased by TNF-α and thus likely plays a critical role in initiating neuroinvasion by SIV/HIV. |
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Authors:
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Nicole A Renner; Nathan S Ivey; Rachel K Redmann; Andrew A Lackner; Andrew G MacLean |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-01-29 |
Journal Detail:
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Title: Journal of neurovirology Volume: 17 ISSN: 1538-2443 ISO Abbreviation: J. Neurovirol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-18 Completed Date: 2011-08-05 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 9508123 Medline TA: J Neurovirol Country: United States |
Other Details:
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Languages: eng Pagination: 146-52 Citation Subset: IM |
Affiliation:
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Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS Dementia Complex
/
genetics,
metabolism*,
pathology* Animals Astrocytes / metabolism*, pathology Brain / metabolism, pathology Cells, Cultured Chemokine CCL7* / genetics, metabolism Gene Expression Gene Expression Profiling HIV / physiology HIV Infections / genetics, metabolism, pathology Humans Lymphocytes / metabolism, pathology Macaca mulatta Macrophages / metabolism, pathology Monocytes / metabolism, pathology RNA, Messenger / analysis Simian Acquired Immunodeficiency Syndrome / genetics, metabolism*, pathology* Simian immunodeficiency virus / physiology Tumor Necrosis Factor-alpha / genetics, metabolism Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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AA13828/AA/NIAAA NIH HHS; MH077544/MH/NIMH NIH HHS; MH61192/MH/NIMH NIH HHS; NS30769/NS/NINDS NIH HHS; P20 RR020159-05/RR/NCRR NIH HHS; P51 RR000164-49/RR/NCRR NIH HHS; P51 RR000168-46/RR/NCRR NIH HHS; R01 MH061192-06/MH/NIMH NIH HHS; R01 MH077544-03S1/MH/NIMH NIH HHS; R01 MH077544-04/MH/NIMH NIH HHS; R01 MH077544-05/MH/NIMH NIH HHS; R01 NS030769-13/NS/NINDS NIH HHS; R21 AA013828-03/AA/NIAAA NIH HHS; RR00164/RR/NCRR NIH HHS; RR00168/RR/NCRR NIH HHS; RR20159/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CCL7; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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