Document Detail


MCP-1-induced protein-1, an immune regulator.
MedLine Citation:
PMID:  23132255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MCP-1-induced protein-1 (MCPIP1) is a newly identified protein that is crucial to immune regulation. Mice lacking MCPIP1 gene suffer from severe immune disorders, and most of them cannot survive longer than 12 weeks. Considerable progress has been made in revealing the mechanism underlying the immune regulatory function of MCPIP1. MCPIP1 can act as an RNase to promote the mRNA degradation of some inflammatory cytokines, such as IL-6 and IL-1. Pre-microRNAs are also confirmed to be the substrate of MCPIP1 RNase. The structure of MCPIP1 N-terminal conserved domain shows a PilT N-terminus-like RNase structure, further supporting the notion that MCPIP1 has RNase activity. MCPIP1 can also deubiquitinate TNF receptor-associated factor family proteins, which are known to mediate immune and inflammatory responses. In this review, we summarize recent progress on the immune regulatory role of MCPIP1 and discuss the mechanisms underlying its function.
Authors:
Jiwei Xu; Sheng Fu; Wei Peng; Zihe Rao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-07
Journal Detail:
Title:  Protein & cell     Volume:  3     ISSN:  1674-8018     ISO Abbreviation:  Protein Cell     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-09-30     Revised Date:  2014-03-13    
Medline Journal Info:
Nlm Unique ID:  101532368     Medline TA:  Protein Cell     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  903-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Humans
Immunity*
Molecular Sequence Data
Ribonucleases / metabolism
Transcription Factors / chemistry,  metabolism*
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / metabolism
Ubiquitination
Chemical
Reg. No./Substance:
0/Transcription Factors; 0/Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; EC 3.1.-/Ribonucleases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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