Document Detail


MCP-1, RANTES, and SDF-1 polymorphisms in Mexican patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  18191726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chemokines and cytokines play an important role in the inflammatory development and progression of autoimmune diseases. The aim of the present study was to evaluate the role of MCP-1, SDF-1, and RANTES polymorphisms as susceptibility markers for systemic lupus erythematosus (SLE) in a group of Mexican patients. MCP-1-2518, SDF-1 G801A, and RANTES-28 polymorphisms were determined in 242 patients with SLE and 220 ethnically matched healthy controls by the polymerase chain reaction-restriction fragment length polymorphism technique. The differences between patients and healthy controls were evaluated by chi(2), Fisher's exact test, and Woolf method for odds ratio. A moderately increased frequency of MCP-1-2518 A allele (p = 0.033, pC = NS) and AA genotype (p = 0.017, pC = NS) existed in SLE patients compared with healthy controls. There was a relationship between polymorphisms and some clinical and laboratory characteristics. SLE patients with and without antiphospholipid syndrome demonstrated different distribution of SDF-1 G801A genotype frequencies. On the other hand, patients with leukopenia, anti-dsDNA, and antiphospholipid autoantibodies demonstrated different MCP-1-2518 genotype distribution compared with patients without these features. Our results suggest that MCP-1 polymorphism is moderately associated with the genetic susceptibility to SLE in Mexican individuals. The polymorphisms could be related to specific clinical and laboratory characteristics in these patients.
Authors:
Guadalupe Lima; Elena Soto-Vega; Yemil Atisha-Fregoso; Jorge Sánchez-Guerrero; Maite Vallejo; Gilberto Vargas-Alarcón; Luis Llorente
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Publication Detail:
Type:  Journal Article     Date:  2007-11-01
Journal Detail:
Title:  Human immunology     Volume:  68     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  980-5     Citation Subset:  IM    
Affiliation:
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Chemokine CCL2 / genetics*
Chemokine CCL5 / genetics*
Chemokine CXCL12 / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Lupus Erythematosus, Systemic / epidemiology,  genetics*
Male
Mexico / epidemiology
Middle Aged
Polymorphism, Genetic*
Chemical
Reg. No./Substance:
0/CCL2 protein, human; 0/Chemokine CCL2; 0/Chemokine CCL5; 0/Chemokine CXCL12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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