| MCP-1: chemoattractant with a role beyond immunity: a review. | |
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MedLine Citation:
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PMID: 20633546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Monocyte Chemoattractant Protein (MCP)-1, a potent monocyte attractant, is a member of the CC chemokine subfamily. MCP-1 exerts its effects through binding to G-protein-coupled receptors on the surface of leukocytes targeted for activation and migration. Role of MCP-1 and its receptor CCR2 in monocyte recruitment during infection or under other inflammatory conditions is well known. METHOD: A comprehensive literature search was conducted from the websites of the National Library of Medicine (http://www.ncbl.nlm.nih.gov) and Pubmed Central, the US National Library of Medicine's digital archive of life sciences literature (http://www.pubmedcentral.nih.gov/). The data was assessed from books and journals that published relevant articles in this field. RESULT: Recent and ongoing research indicates the role of MCP-1 in various allergic conditions, immunodeficiency diseases, bone remodelling, and permeability of blood - brain barrier, atherosclerosis, nephropathies and tumors. CONCLUSION: MCP-1 plays an important role in pathogenesis of various disease states and hence MCP-1 inhibition may have beneficial effects in such conditions. |
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Authors:
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Amita Yadav; Vandana Saini; Sarika Arora |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-07-13 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 411 ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1570-9 Citation Subset: IM |
Copyright Information:
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2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biochemistry, Lady Hardinge Medical College, New Delhi-110001, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemokine CCL2
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antagonists & inhibitors,
physiology* Disease / etiology Drug Delivery Systems Humans Immunity Receptors, CCR2 / physiology |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CCL2; 0/Receptors, CCR2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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