Document Detail


MCL1 is critical for mitochondrial function and autophagy in the heart.
MedLine Citation:
PMID:  24165322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MCL1 (myeloid cell leukemia sequence 1 [BCL2-related]) is an anti-apoptotic BCL2 family protein that is upregulated in several human cancers. In malignancies, overexpression of MCL1 promotes cell survival and confers chemotherapeutic resistance. MCL1 is also highly expressed in normal myocardium, but the functional importance of MCL1 in myocytes has not been explored. We recently discovered that MCL1 plays an essential role in myocardial homeostasis and autophagy. Here, we discuss how loss of MCL1 in the adult mouse heart leads to mitochondrial dysfunction, impaired autophagy and development of heart failure.
Authors:
Robert L Thomas; Asa B Gustafsson
Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-09-05
Journal Detail:
Title:  Autophagy     Volume:  9     ISSN:  1554-8635     ISO Abbreviation:  Autophagy     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-12     Completed Date:  2014-06-18     Revised Date:  2014-11-01    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1902-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autophagy / genetics*
Heart Failure / genetics*
Proto-Oncogene Proteins c-bcl-2 / genetics*
Grant Support
ID/Acronym/Agency:
R01HL087023/HL/NHLBI NIH HHS; R01HL101217/HL/NHLBI NIH HHS; T32 GM007198/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-bcl-2
Comments/Corrections
Comment On:
Genes Dev. 2013 Jun 15;27(12):1365-77   [PMID:  23788623 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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