| MCL-1 (myosin light chains-1) in differential diagnosis of dyspnea. | |
MedLine Citation:
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PMID: 16170394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myosin light chains-1 (MLC-1) have been recently associated with the markers of heart function (NYHA, LVEF, NT-proBNP). Verification of the relationship between markers of heart function (New York Heart Association classification (NYHA), left ventricle ejection fraction determination (LVEF), N terminal prohormone of natriuretic peptide B type BNP (NT-proBNP) and concentrations of myosin light chains-1 (MLC-1) was assessed. Patients examined for dyspnea without signs of acute coronary syndrome. All patients underwent echocardiography (calculation of left ventricle ejection fraction--LVEF) and in the serum of all subjects NT-proBNP (ELEIA) and MLC-1 (ELISA) were determined. In the 38 patients (21 men, 17 women), mean age of 58 years (+/-12 years as 1 SD), a significant negative correlation was found between NT-proBNP and LVEF (r = - 0.47; p = 0.02, Spearman). The median levels of NT pro-BNP were closely associated with NYHA classification (type II--584 ng/l, type III--2792 ng/l, type IV--6400 ng/l; p < 0.05). Individuals with clinical NYHA IV differed significantly in median MLC-1 concentrations from persons with clinical NYHA classification II and III (type II--5.7 ng/l, type III--8.9 ng/l, type IV--17 ng/l; p < 0.05). A significant negative correlation between MLC-1 and LVEF (-0.35; p < 0.03) and significant positive correlations between MLC-1 and NT-proBNP (0.42; p < 0.012) were found. In conclusion MLC-1 cannot be used as a diagnostic marker in differential diagnosis of dyspnea. |
Authors:
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David Stejskal; Borek Lacnák; Katerina Andelová; Marcela Skvarilová; Josef Bartek |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia Volume: 149 ISSN: 1213-8118 ISO Abbreviation: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-09-19 Completed Date: 2006-06-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101140142 Medline TA: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 89-91 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, Hospital Sternberk, Czech Republic. david.stejskal@quick.cz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Diagnosis, Differential Dyspnea / etiology* Female Heart Failure / complications, diagnosis*, physiopathology Humans Male Middle Aged Myosin Light Chains / blood* Natriuretic Peptide, Brain / blood Peptide Fragments / blood ROC Curve Sensitivity and Specificity Stroke Volume |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Myosin Light Chains; 0/Peptide Fragments; 0/myosin light chain I; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
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