Document Detail

MCL-1 (myosin light chains-1) in differential diagnosis of dyspnea.
MedLine Citation:
PMID:  16170394     Owner:  NLM     Status:  MEDLINE    
Myosin light chains-1 (MLC-1) have been recently associated with the markers of heart function (NYHA, LVEF, NT-proBNP). Verification of the relationship between markers of heart function (New York Heart Association classification (NYHA), left ventricle ejection fraction determination (LVEF), N terminal prohormone of natriuretic peptide B type BNP (NT-proBNP) and concentrations of myosin light chains-1 (MLC-1) was assessed. Patients examined for dyspnea without signs of acute coronary syndrome. All patients underwent echocardiography (calculation of left ventricle ejection fraction--LVEF) and in the serum of all subjects NT-proBNP (ELEIA) and MLC-1 (ELISA) were determined. In the 38 patients (21 men, 17 women), mean age of 58 years (+/-12 years as 1 SD), a significant negative correlation was found between NT-proBNP and LVEF (r = - 0.47; p = 0.02, Spearman). The median levels of NT pro-BNP were closely associated with NYHA classification (type II--584 ng/l, type III--2792 ng/l, type IV--6400 ng/l; p < 0.05). Individuals with clinical NYHA IV differed significantly in median MLC-1 concentrations from persons with clinical NYHA classification II and III (type II--5.7 ng/l, type III--8.9 ng/l, type IV--17 ng/l; p < 0.05). A significant negative correlation between MLC-1 and LVEF (-0.35; p < 0.03) and significant positive correlations between MLC-1 and NT-proBNP (0.42; p < 0.012) were found. In conclusion MLC-1 cannot be used as a diagnostic marker in differential diagnosis of dyspnea.
David Stejskal; Borek Lacnák; Katerina Andelová; Marcela Skvarilová; Josef Bartek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia     Volume:  149     ISSN:  1213-8118     ISO Abbreviation:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-09-19     Completed Date:  2006-06-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101140142     Medline TA:  Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  89-91     Citation Subset:  IM    
Department of Laboratory Medicine, Hospital Sternberk, Czech Republic.
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MeSH Terms
Biological Markers / blood
Diagnosis, Differential
Dyspnea / etiology*
Heart Failure / complications,  diagnosis*,  physiopathology
Middle Aged
Myosin Light Chains / blood*
Natriuretic Peptide, Brain / blood
Peptide Fragments / blood
ROC Curve
Sensitivity and Specificity
Stroke Volume
Reg. No./Substance:
0/Biological Markers; 0/Myosin Light Chains; 0/Peptide Fragments; 0/myosin light chain I; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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