| MCI-154, a Ca2+ sensitizer, decreases the oxygen cost of contractility in isolated canine hearts. | |
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MedLine Citation:
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PMID: 9362231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An increase in the responsiveness of the contractile machinery to Ca2+ could theoretically enhance the mechanoenergetics of the heart. To clarify this unresolved issue, we studied the effects of MCI-154, a Ca2+ sensitizer, on the mechanoenergetics in terms of the left ventricular contractility index [slope of end-systolic pressure-volume relationship (Emax)] and the relationship between myocardial oxygen consumption (VO2) and left ventricular pressure-volume area in excised cross-circulated canine hearts. MCI-154 increased Emax by 42 +/- 31% (SD), although the slope of the VO2-PVA relationship (an indicator of contractile efficiency) was unchanged by MCI-154. Despite equal increases in Emax, the relative increase in unloaded VO2 (delta VO2/delta Emax) during infusion of MCI-154 was, however, significantly less than that during CaCl2 infusion (0.0016 +/- 0.0018 vs. 0.0059 +/- 0.0054; P < 0.05). By contrast, delta VO2/delta Emax for milrinone was the same as that for CaCl2 (0.0043 +/- 0.0041 vs. 0.0039 +/- 0.0045; P > 0.05). Basal metabolism in KCl-arrested hearts was unchanged by MCI-154, indicating that MCI-154 consumes less energy than CaCl2 for excitation-contraction coupling. These findings suggest that MCI-154 acts energetically as a Ca2+ sensitizer in beating canine whole hearts. |
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Authors:
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K Onishi; K Sekioka; R Ishisu; Y Abe; H Tanaka; M Nakamura; Y Ueda; T Nakano |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 273 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-12-10 Completed Date: 1997-12-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1688-95 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Blood Volume / drug effects Calcium / metabolism* Dogs Energy Metabolism / drug effects Heart Arrest, Induced Myocardial Contraction / drug effects* Myocardium / metabolism* Oxygen Consumption / drug effects* Potassium Chloride / pharmacology Pyridazines / pharmacology* Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Pyridazines; 7440-70-2/Calcium; 7447-40-7/Potassium Chloride; 98326-33-1/MCI 154 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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