Document Detail


MCH-containing neurons in the hypothalamus of the cat: searching for a role in the control of sleep and wakefulness.
MedLine Citation:
PMID:  17027934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurons that utilize melanin-concentrating hormone (MCH) and others that employ hypocretin as neurotransmitter are located in the hypothalamus and project diffusely throughout the CNS, including areas that participate in the generation and maintenance of the states of sleep and wakefulness. In the present report, immunohistochemical methods were employed to examine the distribution of MCHergic and hypocretinergic neurons. In order to test the hypothesis that the MCHergic system is capable of influencing specific behavioral states, we studied Fos immunoreactivity in MCH-containing neurons during (1) quiet wakefulness, (2) active wakefulness with motor activity, (3) active wakefulness without motor activity, (4) quiet sleep and (5) active sleep induced by carbachol (AS-carbachol). We determined that MCHergic neuronal somata in the cat are intermingled with hypocretinergic neurons in the dorsal and lateral hypothalamus, principally in the tuberal and tuberomammillary regions; however, hypocretinergic neurons extended more in the anterior-posterior axis than MCHergic neurons. Axosomatic and axodendritic contacts were common between these neurons. In contrast to hypocretinergic neurons, which are known to be active during motor activity and AS-carbachol, Fos immunoreactivity was not observed in MCH-containing neurons in conjunction with any of the preceding behavioral conditions. Non-MCHergic, non-hypocretinergic neurons that expressed c-fos during active wakefulness with motor activity were intermingled with MCH and hypocretin-containing neurons, suggesting that these neurons are related to some aspect of motor function. Further studies are required to elucidate the functional sequela of the interactions between MCHergic and hypocretinergic neurons and the phenotype of the other neurons that were active during motor activity.
Authors:
Pablo Torterolo; Sharon Sampogna; Francisco R Morales; Michael H Chase
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-10-09
Journal Detail:
Title:  Brain research     Volume:  1119     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-03     Completed Date:  2007-01-26     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  101-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / metabolism
Animals
Carbachol / pharmacology
Cats
Cholinergic Agonists / pharmacology
Hypothalamic Hormones / metabolism*
Hypothalamus / cytology,  drug effects,  metabolism*
Immunohistochemistry
Intracellular Signaling Peptides and Proteins / metabolism
Melanins / metabolism*
Motor Activity / drug effects,  physiology
Movement / drug effects,  physiology
Neural Pathways / cytology,  drug effects,  metabolism*
Neurons / cytology,  drug effects,  metabolism*
Neuropeptides / metabolism
Pituitary Hormones / metabolism*
Proto-Oncogene Proteins c-fos / metabolism
Sleep / drug effects,  physiology*
Sleep, REM / drug effects,  physiology
Synapses / metabolism,  ultrastructure
Wakefulness / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
AG04307/AG/NIA NIH HHS; HL602969/HL/NHLBI NIH HHS; MH 69372/MH/NIMH NIH HHS; MH43362/MH/NIMH NIH HHS; NS09999/NS/NINDS NIH HHS; NS23426/NS/NINDS NIH HHS; R01 AG004307/AG/NIA NIH HHS; R01 NS023426/NS/NINDS NIH HHS; R01 NS023426-13/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Cholinergic Agonists; 0/Hypothalamic Hormones; 0/Intracellular Signaling Peptides and Proteins; 0/Melanins; 0/Neuropeptides; 0/Pituitary Hormones; 0/Proto-Oncogene Proteins c-fos; 0/orexins; 51-83-2/Carbachol; 67382-96-1/melanin-concentrating hormone; N9YNS0M02X/Acetylcholine
Comments/Corrections

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