Document Detail

MC540 and upconverting nanocrystal coloaded polymeric liposome for near-infrared light triggered photodynamic therapy and cell fluorescent imaging.
MedLine Citation:
PMID:  24511877     Owner:  NLM     Status:  Publisher    
In clinic, the application of photodynamic therapy (PDT) in deep tissue is severely constrained by the limited penetration depth of visible light needed for activating the photosensitizer (PS). In this article, merocyanine 540 (MC540) and upcoverting nanoparticle (UCN) coloaded functional polymeric liposome nanocarrier, (MC540+UCN)/FPL was designed and constructed successfully for solving this problem in PDT. Compared with the conventional approaches using UCN absorbing PS directly, the combination of UCN and polymeric liposome has unique advantages. The UCN core as a transducer can convert deep-penetrating near-infrared (NIR) light to visible light for activating the MC540. The functional polymeric liposome shell decorated with folate as a nanoshield can keep the UCN and MC540 stable, protect them from being attacked and help them get into cells. The results show that the (MC540+UCN)/FPL is individual nanosphere with an average size of 26 nm. The MC540 can be activated to produce singlet oxygen successfully by the upconverting fluorescence emitted from UCNs. After (MC540+UCN)/FPL was modified with folate, the cell uptake efficiency increased obviously. More interestingly, in the PDT effect test, the (MC540+UCN)/FPL nanocarrier further improved the inhibition effect on tumor cells by anchoring targeting folate and TAT peptide. Our data suggests that the (MC540+UCN)/FPL nanocarrier may be a useful nanoplatform for future PDT treatment in deep-cancer therapy based on upcoversion mechanism.
Hanjie Wang; Zhongyun Liu; Sheng Wang; Chunhong Dong; Xiaoqun Gong; Peiqi Zhao; Jin Chang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-10
Journal Detail:
Title:  ACS applied materials & interfaces     Volume:  -     ISSN:  1944-8252     ISO Abbreviation:  ACS Appl Mater Interfaces     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504991     Medline TA:  ACS Appl Mater Interfaces     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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