Document Detail


The MBL2 'LYQA secretor' haplotype is an independent predictor of postoperative myocardial infarction in whites undergoing coronary artery bypass graft surgery.
MedLine Citation:
PMID:  17846289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Mannose-binding lectin (MBL) is an important component of innate immunity and activator of the lectin complement pathway. Within the MBL2 gene are seven 5' "secretor" haplotypes that code for altered serum MBL levels and complement activation. However, recent evidence suggests that 3' MBL2 haplotypes may also modify MBL function and circulating levels. Because MBL and the lectin complement pathway have been implicated in cardiovascular injury, we investigated whether MBL2 haplotypes are independently associated with an increased risk of postoperative myocardial infarction (PMI) in patients undergoing coronary artery bypass graft surgery.
METHODS AND RESULTS: Genotyping of 18 polymorphic sites within the MBL2 gene was performed in a prospective, longitudinal multi-institutional study of 978 patients undergoing primary coronary artery bypass graft-only surgery with cardiopulmonary bypass between August 2001 and May 2005. After adjustment for multiple comparisons by permutation testing, multivariate, stepwise logistic regression, including a score test, was performed controlling for patient demographics, preoperative risk factors, medications, and intraoperative variables to determine if MBL2 secretor haplotypes are independent predictors of PMI in whites undergoing primary coronary artery bypass graft surgery. Neither the 5' nor 3' MBL2 haplotypes alone were associated with an increased incidence of PMI. However, the incidence of PMI in whites (n=843) expressing the combined MBL2 5' LYQA secretor haplotype (CGTCGG) and 3' haplotype (CGGGT) was significantly higher than in whites not expressing the haplotype (38% versus 10%; P<0.007). Moreover, the combined MBL2 LYQA secretor haplotype was an independent predictor of PMI in whites after primary coronary artery bypass graft surgery after adjustment for other covariates (P<0.02; adjusted OR: 3.97; 95% CI: 1.30 to 12.07). The combined MBL2 LYQA secretor haplotype in whites was also an independent predictor of postoperative CKMB levels exceeding 60 ng/mL (P<0.02; adjusted OR: 4.48; 95% CI: 1.95 to 16.80). Inclusion of the combined MBL2 LYQA secretor haplotype improved prediction models for PMI based on traditional risk factors alone (C-statistic 0.715 versus 0.705).
CONCLUSIONS: The combined MBL2 LYQA secretor haplotype is a novel independent predictor of PMI and may aid in preoperative risk stratification of whites undergoing primary coronary artery bypass graft surgery.
Authors:
Charles D Collard; Stanton K Shernan; Amanda A Fox; Toralf Bernig; Stephen J Chanock; William K Vaughn; Kazue Takahashi; Alan B Ezekowitz; Petr Jarolim; Simon C Body
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  116     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-11     Completed Date:  2007-10-11     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  I106-12     Citation Subset:  AIM; IM    
Affiliation:
Baylor College of Medicine, Texas Heart Institute, St Luke's Episcopal Hospital, 6720 Bertner Avenue, Houston, TX 77030, USA. ccollard@heart.thi.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Artery Bypass / adverse effects*
European Continental Ancestry Group / genetics*
Female
Genotype
Haplotypes / genetics*
Humans
Longitudinal Studies
Male
Mannose-Binding Lectin / genetics*
Middle Aged
Myocardial Infarction / epidemiology,  etiology,  genetics*
Polymorphism, Genetic / genetics
Postoperative Complications* / epidemiology,  etiology
Predictive Value of Tests
Prospective Studies
Grant Support
ID/Acronym/Agency:
HL-068774/HL/NHLBI NIH HHS; K23 HL068774-01A1/HL/NHLBI NIH HHS; M01 02558//PHS HHS
Chemical
Reg. No./Substance:
0/MBL2 protein, human; 0/Mannose-Binding Lectin
Comments/Corrections

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