Document Detail


MAP/microtubule affinity-regulating kinases, microtubule dynamics, and spermatogenesis.
MedLine Citation:
PMID:  23449618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During spermatogenesis, spermatids derived from meiosis simultaneously undergo extensive morphological transformation, to become highly specialized and metabolically quiescent cells, and transport across the seminiferous epithelium. Spermatids are also transported back-and-forth across the seminiferous epithelium during the epithelial cycle until they line up at the luminal edge of the tubule to prepare for spermiation at stage VIII of the cycle. Spermatid transport thus requires the intricate coordination of the cytoskeletons in Sertoli cells (SCs) as spermatids are nonmotile cells lacking the ultrastructures of lamellipodia and filopodia, as well as the organized components of the cytoskeletons. In the course of preparing this brief review, we were surprised to see that, except for some earlier eminent morphological studies, little is known about the regulation of the microtubule (MT) cytoskeleton and the coordination of MT with the actin-based cytoskeleton to regulate spermatid transport during the epithelia cycle, illustrating that this is a largely neglected area of research in the field. Herein, we summarize recent findings in the field regarding the significance of actin- and tubulin-based cytoskeletons in SCs that support spermatid transport; we also highlight specific areas of research that deserve attention in future studies.
Authors:
Elizabeth I Tang; Dolores D Mruk; C Yan Cheng
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-04-15
Journal Detail:
Title:  The Journal of endocrinology     Volume:  217     ISSN:  1479-6805     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-16     Completed Date:  2013-06-19     Revised Date:  2013-10-29    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  R13-23     Citation Subset:  IM    
Affiliation:
The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10065, USA.
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MeSH Terms
Descriptor/Qualifier:
Actins / physiology
Animals
Cell Communication / physiology
Cytoskeleton / physiology*
Humans
Male
Microtubules / physiology*
Protein-Serine-Threonine Kinases / physiology*
Sertoli Cells / cytology,  physiology
Spermatids / cytology,  physiology
Spermatogenesis / physiology*
Tubulin / physiology
Grant Support
ID/Acronym/Agency:
R01 HD056034/HD/NICHD NIH HHS; R01 HD056034/HD/NICHD NIH HHS; U54 HD029990/HD/NICHD NIH HHS; U54 HD029990/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Actins; 0/Tubulin; EC 2.7.1.-/MARK1 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases
Comments/Corrections

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