Document Detail


MAPK substrate competition integrates patterning signals in the Drosophila embryo.
MedLine Citation:
PMID:  20171100     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Terminal regions of the Drosophila embryo are patterned by the localized activation of the mitogen-activated protein kinase (MAPK) pathway. This depends on the MAPK-mediated downregulation of Capicua (Cic), a repressor of the terminal gap genes. We establish that downregulation of Cic is antagonized by the anterior patterning morphogen Bicoid (Bcd). We demonstrate that this effect does not depend on transcriptional activity of Bcd and provide evidence suggesting that Bcd, a direct substrate of MAPK, decreases the availability of MAPK for its other substrates, such as Cic. Based on the quantitative analysis of MAPK signaling in multiple mutants, we propose that MAPK substrate competition coordinates the actions of the anterior and terminal patterning systems. In addition, we identify Hunchback as a novel target of MAPK phosphorylation that can account for the previously described genetic interaction between the posterior and terminal systems. Thus, a common enzyme-substrate competition mechanism can integrate the actions of the anterior, posterior, and terminal patterning signals. Substrate competition can be a general signal integration strategy in networks where enzymes, such as MAPK, interact with their multiple regulators and targets.
Authors:
Yoosik Kim; Mathieu Coppey; Rona Grossman; Leiore Ajuria; Gerardo Jiménez; Ze'ev Paroush; Stanislav Y Shvartsman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-02-18
Journal Detail:
Title:  Current biology : CB     Volume:  20     ISSN:  1879-0445     ISO Abbreviation:  Curr. Biol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-07-05     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  446-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / physiology*
Drosophila / embryology*,  enzymology*
Extracellular Signal-Regulated MAP Kinases / genetics,  metabolism
Gene Expression Regulation, Developmental / physiology
Gene Expression Regulation, Enzymologic
Mitogen-Activated Protein Kinases / metabolism*
Signal Transduction
Substrate Specificity
Grant Support
ID/Acronym/Agency:
R01 GM076690/GM/NIGMS NIH HHS; R01 GM076690-03/GM/NIGMS NIH HHS; R01 GM078079/GM/NIGMS NIH HHS; R01 GM078079/GM/NIGMS NIH HHS; R01 GM078079-04/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinases
Comments/Corrections

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