Document Detail


MALT1 and BCL10 aberrations in MALT lymphomas and their effect on the expression of BCL10 in the tumour cells.
MedLine Citation:
PMID:  16341151     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Among the genetic abnormalities reported to occur in mucosa-associated lymphoid tissue (MALT) lymphomas, the three translocations t(11;18)(q21;q21), t(1;14)(p22;q32) and t(14;18)(q32;q21) are of particular interest because they appear to be specific for, or at least closely related to this type of B-cell non-Hodgkin's lymphoma. These translocations affect the MALT1 (18q21) and BCL10 (1p22) genes. We retrieved 77 consecutive biopsies of MALT lymphomas (documented with frozen material) over a 10-year period and investigated these cases for the presence of these three translocations with fluorescence in situ hybridisation, along with the immunohistochemical analysis of the intracellular localisation of the BCL10 protein. The above-listed translocations occurred mutually exclusive and were detected in 10, 1 and 3% of the cases, respectively (the latter incidence being much lower than in the previously reported studies by one single group). These genetic rearrangements corresponded well with the aberrant subcellular localisation of the BCL10 protein as found by immunohistochemistry: t(11;18)(q21;q21) and (1;14)(p22;q32) were marked by a, respectively, moderate to strong nuclear BCL10 staining pattern while t(14;18)(q32;q21)-positive MALT lymphomas were characterised by a perinuclear BCL10 staining pattern. This study further supports the close interaction between the MALT1 and BCL10 proteins in the pathogenesis of MALT lymphomas and may indicate that BCL10 immunohistochemistry is a simple technique to identify those MALT lymphoma cases with an underlying genetic aberration.
Authors:
Xavier Sagaert; Michael Laurent; Mathys Baens; Iwona Wlodarska; Christiane De Wolf-Peeters
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  19     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-20     Completed Date:  2006-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  IM    
Affiliation:
Division of Morphology and Molecular Pathology, Katholieke Universiteit Leuven, Leuven, Belgium. xavier.sagaert@uz.kuleuven.ac.be
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / analysis,  genetics*
Caspases
Chromosomes, Human, Pair 1 / genetics
Chromosomes, Human, Pair 11 / genetics
Chromosomes, Human, Pair 14 / genetics
Chromosomes, Human, Pair 18 / genetics
Gene Rearrangement*
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Karyotyping
Lymphoma, B-Cell, Marginal Zone / genetics,  metabolism,  pathology*
Neoplasm Proteins / genetics*
Translocation, Genetic
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/BCL10 protein, human; 0/Neoplasm Proteins; EC 3.4.22.-/Caspases; EC 3.4.22.-/MALT1 protein, human

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