Document Detail


MALT lymphoma in patients with autoimmune diseases: a comparative analysis of characteristics and clinical course.
MedLine Citation:
PMID:  17554381     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MALT lymphoma, especially of extragastric origin, is thought to be associated with an underlying autoimmune disease (AD) in a significant proportion of patients. No systematic assessment of the clinical characteristics of MALT lymphoma arising in AD as opposed to patients without AD has been performed so far. Therefore, all patients diagnosed and treated for MALT lymphoma at our institution have prospectively undergone routine clinical and serological assessment for AD since 1997. In total, 158 patients were available for analysis, and 61 out of 158 patients (39%) were diagnosed with an underlying AD. Patients with AD were predominantly women and significantly younger at lymphoma diagnosis (56 versus 67 years, P=0.004), with a significantly higher rate of extragastric lymphomas (P=0.012). Furthermore, lymphomas in these patients showed a lower frequency of trisomy 3 (P=0.04) and a significantly lower response rate to Helicobacter pylori eradication therapy in the case of gastric lymphomas (P=0.03). All other parameters including estimated median time to relapse were comparable between both groups. Our data suggest that patients with AD develop MALT lymphoma significantly earlier in life. The clinical course, however, does not appear to be adversely influenced by the presence of AD, as neither rate of relapse nor times to relapse or survival are significantly different.
Authors:
S Wöhrer; M Troch; B Streubel; J Zwerina; C Skrabs; M Formanek; W Hauff; M Hoffmann; L Müllauer; A Chott; M Raderer
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-07
Journal Detail:
Title:  Leukemia     Volume:  21     ISSN:  0887-6924     ISO Abbreviation:  Leukemia     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-09-25     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1812-8     Citation Subset:  IM    
Affiliation:
Division of Bone Marrow Transplantation, Department of Internal Medicine 1, Medical University of Vienna, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Aged
Autoimmune Diseases / complications*,  genetics,  therapy
Female
Humans
Lymphoma, B-Cell, Marginal Zone / complications*,  genetics,  therapy
Male
Middle Aged
Neoplasm Staging
Prognosis

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