Document Detail


MACH14: a multi-site collaboration on ART adherence among 14 institutions.
MedLine Citation:
PMID:  22864921     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The integration of original data from multiple antiretroviral (ARV) adherence studies offers a promising, but little used method to generate evidence to advance the field. This paper provides an overview of the design and implementation of MACH14, a collaborative, multi-site study in which a large data system has been created for integrated analyses by pooling original data from 16 longitudinal ARV adherence studies. Studies selected met specific criteria including similar research design and data domains such as adherence measured with medication event monitoring system, psychosocial factors related to adherence behavior, and virologic and clinical outcomes. The data system created contains individual data (collected between 1997 and 2009) from 2,860 HIV patients. Collaboration helped resolve the challenges inherent in pooling data across multiple studies, yet produced a data system with strong statistical power and potentially greater capacity to address key scientific questions than possible with single-sample studies or even meta-analytic designs.
Authors:
Honghu Liu; Ira B Wilson; Kathy Goggin; Nancy Reynolds; Jane M Simoni; Carol E Golin; Marc I Rosen; Robert Gross; Glenn Wagner; Robert H Remien; Neil Schneiderman; Judith A Erlen; Julia H Arnsten; David R Bangsberg
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  AIDS and behavior     Volume:  17     ISSN:  1573-3254     ISO Abbreviation:  AIDS Behav     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-18     Completed Date:  2013-04-03     Revised Date:  2013-09-16    
Medline Journal Info:
Nlm Unique ID:  9712133     Medline TA:  AIDS Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-41     Citation Subset:  IM    
Affiliation:
Division of Public Health and Community Dentistry, School of Dentistry, University of California, Los Angeles, CA, USA. hhliu@ucla.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anti-HIV Agents
Clinical Trials as Topic
Cooperative Behavior
Data Collection / methods*
Female
HIV Infections / complications,  drug therapy*,  psychology,  virology
Humans
Information Systems
Male
Medication Adherence / statistics & numerical data*
Middle Aged
Socioeconomic Factors
Viral Load / drug effects
Young Adult
Grant Support
ID/Acronym/Agency:
2R01NR04749/NR/NINR NIH HHS; AI069419/AI/NIAID NIH HHS; AI38858/AI/NIAID NIH HHS; K02DA017277/DA/NIDA NIH HHS; K23MH01862/MH/NIMH NIH HHS; K24 MH092242/MH/NIMH NIH HHS; K24 RR020300/RR/NCRR NIH HHS; P01MH49548/MH/NIMH NIH HHS; R01 MH054907/MH/NIMH NIH HHS; R01 MH068197/MH/NIMH NIH HHS; R01 MH078773/MH/NIMH NIH HHS; R01 MH61173/MH/NIMH NIH HHS; R01AI41413/AI/NIAID NIH HHS; R01DA015679/DA/NIDA NIH HHS; R01DA11869/DA/NIDA NIH HHS; R01DA13826/DA/NIDA NIH HHS; R01DA15215/DA/NIDA NIH HHS; R01MH01584/MH/NIMH NIH HHS; R01MH078773/MH/NIMH NIH HHS; R01MH54907/MH/NIMH NIH HHS; R01MH58986/MH/NIMH NIH HHS; R01MH61695/MH/NIMH NIH HHS; R01MH68197/MH/NIMH NIH HHS; R01NR04749/NR/NINR NIH HHS
Chemical
Reg. No./Substance:
0/Anti-HIV Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antiparasitic efficacy of piperine against Argulus spp. on Carassius auratus (Linn. 1758): in vitro ...
Next Document:  Biocompatible polydopamine fluorescent organic nanoparticles: facile preparation and cell imaging.