Document Detail


MAC of desflurane in 60% nitrous oxide in infants and children.
MedLine Citation:
PMID:  1539844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Desflurane, an inhaled anesthetic, may be useful for outpatient procedures in pediatric patients because its blood solubility (similar to that of nitrous oxide and less than that of commercially available potent inhaled anesthetics) may facilitate emergence and recovery from anesthesia. Although the MAC of desflurane without nitrous oxide has been determined in pediatric patients, it is likely that clinicians will administer desflurane with nitrous oxide. To determine the potency of desflurane administered with 60% nitrous oxide in pediatric patients, the authors determined the minimum alveolar concentration that prevents movement in 50% of subjects (MAC) in 12 infants aged 17 weeks-12 months and 12 children aged 1-5 yr. Anesthesia was induced with desflurane in oxygen; nitrous oxide was not administered during induction of anesthesia to minimize the likelihood of hypoxia if laryngospasm occurred. Following tracheal intubation, nitrous oxide and desflurane were administered and maintained at target concentrations for a minimum of 10 min before surgical incision. No additional anesthetic, sedative/hypnotic, or analgesic drugs were administered prior to incision. Following surgical incision, anesthesia was maintained with nitrous oxide, desflurane, and fentanyl, 4 +/- 1 micrograms/kg (mean +/- SD). MAC, determined using a modification of Dixon's "up-and-down" technique, was 7.5 +/- 0.1% (mean +/- SE) for infants and 6.4 +/- 0.2% for children; similar values were obtained using logistic regression (7.5 +/- 0.01% and 6.3 +/- 0.03%, respectively). Time from discontinuation of anesthesia to eye-opening and tracheal extubation was 5.4 +/- 3.6 min (mean +/- SD).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
D M Fisher; M S Zwass
Related Documents :
6609864 - Effect of segmental epidural analgesia on changes in peripheral blood leucocyte counts,...
2859814 - Vecuronium and porcine malignant hyperthermia.
22289564 - Evaluation of neonatal pneumothorax.
25249774 - Alternative parameterizations of relatedness in whole genome association analysis of pr...
16023454 - Congenital diaphragmatic hernia: searching for answers.
17300954 - Seasonality in birth weight in israel: new evidence suggests several global patterns an...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  76     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-02     Completed Date:  1992-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  354-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia, University of California, San Francisco 94143-0648.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anesthesia, Inhalation*
Child, Preschool
Humans
Infant
Isoflurane / administration & dosage,  analogs & derivatives*
Nitrous Oxide / administration & dosage*
Chemical
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 26675-46-7/Isoflurane; 57041-67-5/desflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic dr...
Next Document:  A double-blinded comparison of metoclopramide and droperidol for prevention of emesis following stra...