Document Detail


M2b monocytes predominated in peripheral blood of severely burned patients.
MedLine Citation:
PMID:  21068408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Severely burned patients were shown to be carriers of M2 monocytes, and all of the monocytes isolated from peripheral blood of severely burned patients (19 of 19 patients) were demonstrated as M2b monocytes (IL-12(-)IL-10(+)CCL1(+) monocytes). Low levels of M2a (IL-12(-)IL-10(+)CCL17(+) monocytes) and M2c monocytes (IL-12(-)IL-10(+)CXCL13(+) monocytes) were demonstrated in peripheral blood of severely burned patients (M2a, 2 of 19 patients; M2c, 5 of 19 patients). M2b, M2a, and M2c monocytes were not detected in peripheral blood of healthy donors. However, M2b monocytes appeared when healthy donor monocytes were cultured in media supplemented with burn patient serum (15%). CCL2 was detected in sera of all burn patients, and M2b monocytes were not generated from healthy donor monocytes cultured with media containing 15% burn patient sera that were previously treated with anti-CCL2 mAb. In addition, M2b monocytes were generated from healthy donor monocytes in cultures supplemented with rCCL2. These results indicate that M2b monocytes are predominant in peripheral blood of severely burned patients who are carriers of CCL2 that functions to stimulate monocyte conversion from resident monocytes to M2b monocytes.
Authors:
Makiko Kobayashi; Marc G Jeschke; Kenji Shigematsu; Akira Asai; Shohei Yoshida; David N Herndon; Fujio Suzuki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-10
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  185     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7174-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antigens, Differentiation / blood,  immunology*
Burns / blood,  immunology*,  pathology
Chemokine CCL2 / blood,  immunology*
Child
Child, Preschool
Female
Humans
Infant
Male
Monocytes / immunology*,  metabolism,  pathology
Serum / immunology*,  metabolism
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Antigens, Differentiation; 0/CCL2 protein, human; 0/Chemokine CCL2

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