Document Detail


The M235T variant of the angiotensinogen gene and the body mass index are useful markers for prevention of hypertension in pregnancy: a tree-based analysis of gene-environment interaction.
MedLine Citation:
PMID:  12536339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We sought to perform a tree-based analysis of lifestyle risk factors for hypertension in pregnancy (HP) with univariate and multivariate analyses. Seventy-eight HP patients and 199 normal controls were recruited from primiparous women 20 to 34 years of age. Data from angiotensinogen (AGT) genotyping and data from a self-administered questionnaire about lifestyle were subjected to univariate and multivariate analyses. By dividing the subjects into two subgroups--those who possessed "the TT genotype of AGT" and "body mass index (BMI) < 24" and those who did not--we were able to examine the acquired risk factors for HP during pregnancy in these two groups. Multivariate analysis selected "mentally stressful condition" and "no antenatal training during pregnancy" in the former group, and "poorly balanced diet" in the latter group. Determination of factors obvious before pregnancy, such as genotype or prepregnancy BMI, may be useful for devising effective individualized strategies for preventing HP.
Authors:
Gen Kobashi; Akira Hata; Koichi Shido; Kaori Ohta; Hideto Yamada; Seiichiro Fujimoto; Kiyotaro Kondo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Seminars in thrombosis and hemostasis     Volume:  28     ISSN:  0094-6176     ISO Abbreviation:  Semin. Thromb. Hemost.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-21     Completed Date:  2003-06-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0431155     Medline TA:  Semin Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  501-6     Citation Subset:  IM    
Affiliation:
Division of Preventive Medicine, Hokkaido University Graduate School of Medicine, N15W7, Sapporo 060-8638, Japan. genkoba@med.hokudai.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiotensinogen / genetics*
Body Mass Index
Case-Control Studies
Female
Genetic Markers
Genetic Variation
Genotype
Humans
Hypertension / complications,  genetics*,  pathology,  prevention & control*
Multivariate Analysis
Pregnancy
Pregnancy Complications, Cardiovascular / etiology*,  pathology,  prevention & control*
Risk Factors
Chemical
Reg. No./Substance:
0/Genetic Markers; 11002-13-4/Angiotensinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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