Document Detail


The M2 protein of influenza A virus is acylated.
MedLine Citation:
PMID:  2045796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The M2 protein of influenza A virus, a 97 amino acid integral membrane protein expressed on the surface of infected cells, is covalently modified with long chain fatty acids. The fatty acid bond is sensitive to treatment with neutral hydroxylamine and mercaptoethanol, which indicates a labile thioester type linkage. Thin-layer chromatographic fatty acid analysis of [3H]myristic and [3H]palmitic acid-labelled M2 protein shows that palmitic acid is the predominant fatty acid linked to this polypeptide. Palmitoylation of M2 occurs post-translationally and causes an upward shift in the SDS-PAGE mobility of the protein.
Authors:
M Veit; H D Klenk; A Kendal; R Rott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of general virology     Volume:  72 ( Pt 6)     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-17     Completed Date:  1991-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1461-5     Citation Subset:  IM    
Affiliation:
Institut für Virologie, Philipps-Universität Marburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acylation
Animals
Autoradiography
Cell Line
Cysteine / metabolism
Influenza A virus / metabolism*
Myristic Acid
Myristic Acids / metabolism*
Palmitic Acid
Palmitic Acids / metabolism*
Protein Processing, Post-Translational
Sulfur Radioisotopes
Tritium
Viral Matrix Proteins / biosynthesis*,  genetics,  isolation & purification
Chemical
Reg. No./Substance:
0/M-protein, influenza virus; 0/M2 protein, Influenza A virus; 0/Myristic Acids; 0/Palmitic Acids; 0/Sulfur Radioisotopes; 0/Viral Matrix Proteins; 10028-17-8/Tritium; 52-90-4/Cysteine; 544-63-8/Myristic Acid; 57-10-3/Palmitic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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