| The M2 protein of influenza A virus is acylated. | |
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MedLine Citation:
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PMID: 2045796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The M2 protein of influenza A virus, a 97 amino acid integral membrane protein expressed on the surface of infected cells, is covalently modified with long chain fatty acids. The fatty acid bond is sensitive to treatment with neutral hydroxylamine and mercaptoethanol, which indicates a labile thioester type linkage. Thin-layer chromatographic fatty acid analysis of [3H]myristic and [3H]palmitic acid-labelled M2 protein shows that palmitic acid is the predominant fatty acid linked to this polypeptide. Palmitoylation of M2 occurs post-translationally and causes an upward shift in the SDS-PAGE mobility of the protein. |
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Authors:
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M Veit; H D Klenk; A Kendal; R Rott |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of general virology Volume: 72 ( Pt 6) ISSN: 0022-1317 ISO Abbreviation: J. Gen. Virol. Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-07-17 Completed Date: 1991-07-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077340 Medline TA: J Gen Virol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1461-5 Citation Subset: IM |
Affiliation:
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Institut für Virologie, Philipps-Universität Marburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acylation Animals Autoradiography Cell Line Cysteine / metabolism Influenza A virus / metabolism* Myristic Acid Myristic Acids / metabolism* Palmitic Acid Palmitic Acids / metabolism* Protein Processing, Post-Translational Sulfur Radioisotopes Tritium Viral Matrix Proteins / biosynthesis*, genetics, isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/M-protein, influenza virus; 0/M2 protein, Influenza A virus; 0/Myristic Acids; 0/Palmitic Acids; 0/Sulfur Radioisotopes; 0/Viral Matrix Proteins; 10028-17-8/Tritium; 52-90-4/Cysteine; 544-63-8/Myristic Acid; 57-10-3/Palmitic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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