Document Detail


Lytic transglycosylases in macromolecular transport systems of Gram-negative bacteria.
MedLine Citation:
PMID:  14625683     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cell wall of Gram-negative bacteria is essential for the integrity of the bacterial cell but also imposes a physical barrier to trans-envelope transport processes in which DNA and/or proteins are taken up or secreted by complex protein assemblies. The presence of genes encoding lytic transglycosylases in macromolecular transport systems (bacteriophage entry, type II secretion and type IV pilus synthesis, type III secretion, type IV secretion) suggests an important role for these specialised cell-wall-degrading enzymes. Such enzymes are capable of locally enlarging gaps in the peptidoglycan meshwork to allow the efficient assembly and anchoring of supramolecular transport complexes in the cell envelope. In this review, current knowledge on the role and distribution of these specialised murein-degrading enzymes in diverse macromolecular transport systems is summarised and discussed.
Authors:
G Koraimann
Related Documents :
9635513 - Uptake of doxorubicin by cultured kidney epithelial cells llc-pk1.
1760943 - Daunorubicin impairs 1-beta-d-arabinofuranosylcytosine uptake.
8543313 - Proliferative characteristics of differentiated cells in familial adenomatous polyposis...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  60     ISSN:  1420-682X     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-19     Completed Date:  2004-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  2371-88     Citation Subset:  IM    
Affiliation:
Institut für Molekularbiologie, Biochemie und Mikrobiologie, Karl-Franzens-Universität Graz, Universitätsplatz 2, 8010 Graz, Austria. guenther.koraimann@uni-graz.at
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Bacteriophages / physiology
Cell Wall / metabolism
DNA / metabolism
Fimbriae, Bacterial / physiology
Glycosyltransferases / chemistry,  physiology*
Gram-Negative Bacteria / metabolism*,  pathogenicity
Molecular Sequence Data
Peptidoglycan / metabolism
Protein Transport
Chemical
Reg. No./Substance:
0/Peptidoglycan; 9007-49-2/DNA; EC 2.4.-/Glycosyltransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Structure and morphogenesis of bacteriophage T4.
Next Document:  Cell cycle regulation by the B-Myb transcription factor.