Document Detail

Lytic EBV infection in epithelial cells but not in B lymphocytes is dependent on Blimp1.
MedLine Citation:
PMID:  22278826     Owner:  NLM     Status:  Publisher    
Epstein-Barr virus (EBV) replicates in superficial differentiated cells of oral hairy leukoplakia (OHL). Differentiation of squamous epithelial cells depends on B lymphocyte-induced maturation protein-1 (Blimp1). Here we show that expression of the EBV immediate early protein, BZLF1, is restricted to Blimp1-positive epithelial cells in OHL. Luciferase assays revealed Blimp1-dependent induction of the BZLF1 promoter, Zp, in epithelial cell lines. Expression of ZEB1, a negative regulator of Zp, and of Xbp-1, which mediates the Blimp-1 effect on Zp in B-cells, were not affected by enforced Blimp1 expression. Moreover, Xbp-1 protein expression was not detected in differentiated epithelial cells of OHL. Thus, Blimp1 induces BZLF1 expression in epithelial cells independently of ZEB1 and Xbp-1. In contrast to epithelial cells of OHL, BZLF1 expression was also observed in Blimp1-negative lymphoid cells in infectious mononucleosis tonsils, suggesting that EBV replication in B-cells may be induced independently of terminal differentiation.
Maike Buettner; Anke Lang; Christiane S Tudor; Birgit Meyer; Alan Cruchley; Mario Hm Barros; Paul Farrell; Hans-Martin Jäck; Wolfgang Schuh; Gerald Niedobitek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-25
Journal Detail:
Title:  The Journal of general virology     Volume:  -     ISSN:  1465-2099     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Universitätsklinikum Erlangen, Germany;
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