| Lytic EBV infection in epithelial cells but not in B lymphocytes is dependent on Blimp1. | |
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MedLine Citation:
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PMID: 22278826 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Epstein-Barr virus (EBV) replicates in superficial differentiated cells of oral hairy leukoplakia (OHL). Differentiation of squamous epithelial cells depends on B lymphocyte-induced maturation protein-1 (Blimp1). Here we show that expression of the EBV immediate early protein, BZLF1, is restricted to Blimp1-positive epithelial cells in OHL. Luciferase assays revealed Blimp1-dependent induction of the BZLF1 promoter, Zp, in epithelial cell lines. Expression of ZEB1, a negative regulator of Zp, and of Xbp-1, which mediates the Blimp-1 effect on Zp in B-cells, were not affected by enforced Blimp1 expression. Moreover, Xbp-1 protein expression was not detected in differentiated epithelial cells of OHL. Thus, Blimp1 induces BZLF1 expression in epithelial cells independently of ZEB1 and Xbp-1. In contrast to epithelial cells of OHL, BZLF1 expression was also observed in Blimp1-negative lymphoid cells in infectious mononucleosis tonsils, suggesting that EBV replication in B-cells may be induced independently of terminal differentiation. |
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Authors:
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Maike Buettner; Anke Lang; Christiane S Tudor; Birgit Meyer; Alan Cruchley; Mario Hm Barros; Paul Farrell; Hans-Martin Jäck; Wolfgang Schuh; Gerald Niedobitek |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: The Journal of general virology Volume: - ISSN: 1465-2099 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0077340 Medline TA: J Gen Virol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Universitätsklinikum Erlangen, Germany; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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