Document Detail

Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm.
MedLine Citation:
PMID:  19683237     Owner:  NLM     Status:  MEDLINE    
Lysyl oxidase (LOX) is an enzyme critical for the stability of extracellular matrix and also known to have diverse biological functions. Little is known, however, about the role of LOX in regulating inflammation. Here we demonstrate that LOX suppresses secretion of monocyte chemoattractant protein-1 (MCP-1) in cultured vascular smooth muscle cells. Furthermore, enhancement of LOX activity reduces MCP-1 in a mouse model of abdominal aortic aneurysm (AAA), thereby preventing macrophage infiltration and AAA progression. These findings suggest that LOX has a novel function in resolving inflammation by reducing MCP-1 in AAA.
Masahiko Onoda; Koichi Yoshimura; Hiroki Aoki; Yasuhiro Ikeda; Noriyasu Morikage; Akira Furutani; Masunori Matsuzaki; Kimikazu Hamano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-23
Journal Detail:
Title:  Atherosclerosis     Volume:  208     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  366-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami Kogushi, Ube, Japan.
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MeSH Terms
Adenoviridae / metabolism
Aortic Aneurysm, Abdominal / metabolism*,  therapy
Chemokine CCL2 / metabolism*
Cytokines / metabolism
Disease Progression
Macrophages / metabolism
Muscle, Smooth, Vascular / cytology
Protein-Lysine 6-Oxidase / metabolism,  physiology*
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/Chemokine CCL2; 0/Cytokines; EC 6-Oxidase

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