| Lysozyme overexpression in fundic gland polyps. | |
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MedLine Citation:
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PMID: 20393030 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Backgroud: Helicobacter pylori (Hp) rarely proliferates in patients with fundic gland polyps (FGPs). We recently found that FGPs express lysozyme, one of the natural defence substances against infection. We aimed to assess the degree of lysozyme expression in a cohort of consecutive FGPs. MATERIALS AND METHODS: A total of 153 gastric biopsies were investigated: 93 with FGPs, 30 with normal mucosa (Nm), 15 with Hp-induced chronic gastritis (Hp-gastritis) and 15 with chronic gastritis without Hp infection (non-Hp-gastritis). Sections were stained with anti-lysozyme (muramidase). RESULTS: Lysozyme was slightly to moderately expressed in the surface and foveolar pits, being markedly expressed in the neck glands in Nm, in non-Hp and Hp-gastritis. The ratio of lysozyme neck glands-foveoli was higher in non-Hp than in Nm and even higher in Hp-gastritis. In FGPs, lysozyme was markedly expressed in the surface, the foveolar pits and the cells that partly or entirely covered the microcysts. Discussion and CONCLUSION: While the moderate expansion of the lysozyme-producing cells of the neck glands in Hp-gastritis might be insufficient to eradicate these bacteria, the overproduction of lysozyme in the epithelium covering FGP could be an explanation for the lack of Hp proliferation in these patients. |
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Authors:
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Carlos A Rubio |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 30 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-15 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 1021-4 Citation Subset: IM |
Affiliation:
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Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden. Carlos.Rubio@ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Chronic Disease Gastric Fundus / enzymology*, microbiology, pathology Gastric Mucosa / enzymology Gastritis / enzymology, microbiology, pathology Helicobacter Infections / enzymology Helicobacter pylori Humans Muramidase / biosynthesis* Polyps / enzymology*, microbiology Stomach Diseases / enzymology*, microbiology, pathology |
| Chemical | |
Reg. No./Substance:
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EC 3.2.1.17/Muramidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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