Document Detail


Lysozyme activity in cerebrospinal fluid. Studies in inflammatory and non-inflammatory CNS disorders.
MedLine Citation:
PMID:  857579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lysozyme activity was measured in cerebrospinal fluid (CSF) from 114 patients with inflammatory (bacterial and serous meningitis, polyradiculitis, encephalitis) and non-inflammatory (multiple sclerosis, CNS tumors, cerebral vascular diseases) CNS diseases. Highly elevated values were found consistently in patients with bacterial meningitis. Elevated values were found also in patients with encephalitis, polyradiculitis, multiple sclerosis and CNS tumors, but a considerable overlapping between these groups and normal controls precludes the use of CSF lysozyme measurements as a diagnostic aid in the latter disease groups. Simultaneous measurements of lysozyme, albumin and IgG in CSF and serum suggested that the mechanism for increased CSF lysozyme values in bacterial meningitis is mainly a breakdown of the blood/brain barrier, whereas the increased CSF lysozyme values in the remaining groups of patients are more likely caused by production of lysozyme by cells within the meninges (neutrophilic granulocytes, monocytes?).
Authors:
N E Hansen; H Karle; A Jensen; E Bock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  55     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-11     Completed Date:  1977-06-11     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  418-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood-Brain Barrier
Brain Neoplasms / enzymology
Central Nervous System Diseases / enzymology*
Cerebrovascular Disorders / enzymology
Encephalitis / enzymology
Humans
Immunoglobulin G / cerebrospinal fluid
Male
Meningitis / enzymology
Multiple Sclerosis / enzymology
Muramidase / blood,  cerebrospinal fluid*
Polyradiculopathy / enzymology
Serum Albumin / cerebrospinal fluid
Chemical
Reg. No./Substance:
0/Immunoglobulin G; 0/Serum Albumin; EC 3.2.1.17/Muramidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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