| Lysozyme activity in cerebrospinal fluid. Studies in inflammatory and non-inflammatory CNS disorders. | |
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MedLine Citation:
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PMID: 857579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lysozyme activity was measured in cerebrospinal fluid (CSF) from 114 patients with inflammatory (bacterial and serous meningitis, polyradiculitis, encephalitis) and non-inflammatory (multiple sclerosis, CNS tumors, cerebral vascular diseases) CNS diseases. Highly elevated values were found consistently in patients with bacterial meningitis. Elevated values were found also in patients with encephalitis, polyradiculitis, multiple sclerosis and CNS tumors, but a considerable overlapping between these groups and normal controls precludes the use of CSF lysozyme measurements as a diagnostic aid in the latter disease groups. Simultaneous measurements of lysozyme, albumin and IgG in CSF and serum suggested that the mechanism for increased CSF lysozyme values in bacterial meningitis is mainly a breakdown of the blood/brain barrier, whereas the increased CSF lysozyme values in the remaining groups of patients are more likely caused by production of lysozyme by cells within the meninges (neutrophilic granulocytes, monocytes?). |
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Authors:
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N E Hansen; H Karle; A Jensen; E Bock |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 55 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 1977 May |
Date Detail:
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Created Date: 1977-06-11 Completed Date: 1977-06-11 Revised Date: 2006-08-16 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 418-24 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood-Brain Barrier Brain Neoplasms / enzymology Central Nervous System Diseases / enzymology* Cerebrovascular Disorders / enzymology Encephalitis / enzymology Humans Immunoglobulin G / cerebrospinal fluid Male Meningitis / enzymology Multiple Sclerosis / enzymology Muramidase / blood, cerebrospinal fluid* Polyradiculopathy / enzymology Serum Albumin / cerebrospinal fluid |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; 0/Serum Albumin; EC 3.2.1.17/Muramidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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