| Lysosomes in apoptosis. | |
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MedLine Citation:
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PMID: 18662570 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lysosomes are specialized organelles for protein recycling and as such are involved in the terminal steps of autophagy. However, it has become evident that lysosomes also play an important role in the progression of apoptosis. This latter function seems to be dependent on lysosomal proteases, which need to be released into the cytosol for apoptosis to be efficient. Among the lysosomal proteases, the most abundant are the cysteine cathepsins and the aspartic protease cathepsin D, which seem to be the major apoptosis mediators. This chapter reviews the methods used to study lysosomes and lysosomal proteases. |
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Authors:
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Saska Ivanova; Urska Repnik; Lea Bojic; Ana Petelin; Vito Turk; Boris Turk |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Methods in enzymology Volume: 442 ISSN: 1557-7988 ISO Abbreviation: Meth. Enzymol. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-07-29 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0212271 Medline TA: Methods Enzymol Country: United States |
Other Details:
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Languages: eng Pagination: 183-99 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Molecular and Structural Biology, J. Stefan Institute, Ljubljana, Slovenia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology* Biological Transport Cathepsin D / metabolism Cathepsins / metabolism Humans Lysosomes / enzymology*, metabolism* Permeability Substrate Specificity |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Cathepsins; EC 3.4.23.5/Cathepsin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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