| Lysosomes: fusion and function. | |
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MedLine Citation:
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PMID: 17637737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lysosomes are dynamic organelles that receive and degrade macromolecules from the secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell imaging has shown that fusion with lysosomes occurs by both transient and full fusion events, and yeast genetics and mammalian cell-free systems have identified much of the protein machinery that coordinates these fusion events. Many pathogens that hijack the endocytic pathways to enter cells have evolved mechanisms to avoid being degraded by the lysosome. However, the function of lysosomes is not restricted to protein degradation: they also fuse with the plasma membrane during cell injury, as well as having more specialized secretory functions in some cell types. |
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Authors:
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J Paul Luzio; Paul R Pryor; Nicholas A Bright |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: 8 ISSN: 1471-0072 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-23 Completed Date: 2007-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 622-32 Citation Subset: IM |
Affiliation:
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Cambridge Institute for Medical Research, Cambridge, CB2 0XY, UK. jpl10@cam.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autophagy* Cell-Free System / metabolism, microbiology, parasitology, secretion, ultrastructure, virology Evolution Humans Lysosomes / metabolism*, microbiology, parasitology, secretion, ultrastructure, virology Membrane Fusion* Phagocytosis* Proteins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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