| Lysosomes, cholesterol and atherosclerosis. | |
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MedLine Citation:
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PMID: 21643524 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cholesterol-engorged macrophage foam cells are a critical component of the atherosclerotic lesion. Reducing the sterol deposits in lesions reduces clinical events. Sterol accumulations within lysosomes have proven to be particularly hard to mobilize out of foam cells. Moreover, excess sterol accumulation in lysosomes has untoward effects, including a complete disruption of lysosome function. Recently, we demonstrated that treatment of sterol-engorged macrophages in culture with triglyceride-containing particles can reverse many of the effects of cholesterol on lysosomes and dramatically reduce the sterol burden in these cells. This article describes what is known about lysosomal sterol engorgement, discusses the possible mechanisms by which triglyceride could produce its effects, and evaluates the possible positive and negative effects of reducing the lysosomal cholesterol levels in foam cells. |
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Authors:
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W Gray Jerome |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Clinical lipidology Volume: 5 ISSN: 1758-4302 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-6-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101502551 Medline TA: Clin Lipidol Country: - |
Other Details:
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Languages: ENG Pagination: 853-865 Citation Subset: - |
Affiliation:
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Department of Pathology, U-2206 Medical Center North Vanderbilt University School of Medicine 1161 21st Avenue, South Nashville, TN 37232-32561, USA, Tel.: +1 615 322 5530. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 HL086746-02//NHLBI NIH HHS; R01 HL086746-03//NHLBI NIH HHS |
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