Document Detail

Lysosome and lysosome-related organelles responsible for specialized functions in higher organisms, with special emphasis on vacuolar-type proton ATPase.
MedLine Citation:
PMID:  14745137     Owner:  NLM     Status:  MEDLINE    
Mammals contain various cells differentiated in both morphology and function, which play vital roles in tissue-specific functions. Late endosome/lysosome and lysosomal-related organelles are involved in these specialized functions including antigen presentation, bone remodeling and hormone regulation. To fulfill these diverse roles, lysosomes are present at different levels in different tissues and cell types; however, their morphology within these different tissues varies and the regulation of their activities differs with lysosomal compartments in some cells also functioning as secretory compartments. The luminal acidification of these organelles is closely correlated with their functions. This review will discuss the functions of lysosomes and lysosomal-related organelles, with particular emphasis on the major proton pump, the vacuolar-type proton ATPase (V-ATPase), which is responsible for luminal acidification.
Ge-Hong Sun-Wada; Yoh Wada; Masamitsu Futai
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cell structure and function     Volume:  28     ISSN:  0386-7196     ISO Abbreviation:  Cell Struct. Funct.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2004-01-27     Completed Date:  2004-09-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7608465     Medline TA:  Cell Struct Funct     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  455-63     Citation Subset:  IM    
Division of Biological Sciences and Nanoscience, Japan Science and Technology Cooperation, Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan.
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MeSH Terms
Acrosome / chemistry,  metabolism
Antigens, CD / metabolism
Hydrogen-Ion Concentration
Kidney / cytology,  metabolism
Lung / cytology,  metabolism
Lysosome-Associated Membrane Glycoproteins
Lysosomes / metabolism*,  ultrastructure
Osteoclasts / metabolism
Protein Subunits / metabolism
Spermatozoa / cytology,  metabolism
Vacuolar Proton-Translocating ATPases / chemistry,  metabolism*
Vacuoles / metabolism*
Reg. No./Substance:
0/Antigens, CD; 0/Lysosome-Associated Membrane Glycoproteins; 0/Protein Subunits; EC 3.6.1.-/Vacuolar Proton-Translocating ATPases

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