| Lysosomal-mitochondrial cross-talk during cell death. | |
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MedLine Citation:
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PMID: 20696281 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Lysosomes are membrane-bound organelles, which contain an arsenal of different hydrolases, enabling them to act as the terminal degradative compartment of the endocytotic, phagocytic and autophagic pathways. During the last decade, it was convincingly shown that destabilization of lysosomal membrane and release of lysosomal content into the cytosol can initiate the lysosomal apoptotic pathway, which is dependent on mitochondria destabilization. The cleavage of BID to t-BID and degradation of anti-apoptotic BCL-2 proteins by lysosomal cysteine cathepsins were identified as links to the mitochondrial cytochrome c release, which eventually leads to caspase activation. There have also been reports about the involvement of lysosome destabilization and lysosomal proteases in the extrinsic apoptotic pathway, although the molecular mechanism is still under debate. In the present article, we discuss the cross-talk between lysosomes and mitochondria during apoptosis and its consequences for the fate of the cell. |
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Authors:
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Urška Repnik; Boris Turk |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-07 |
Journal Detail:
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Title: Mitochondrion Volume: 10 ISSN: 1872-8278 ISO Abbreviation: Mitochondrion Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100968751 Medline TA: Mitochondrion Country: Netherlands |
Other Details:
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Languages: eng Pagination: 662-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Mitochondria Research Society. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia. urska.repnik@ijs.si |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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