| Lysosomal cysteine cathepsins: signaling pathways in apoptosis. | |
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MedLine Citation:
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PMID: 17552902 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apoptosis is the major mechanism by which eukaryotic organisms eliminate potentially dangerous, superfluous and damaged cells. Initially, nuclei and mitochondria were found to be the key organelles involved in the process. However, recent data suggest that lysosomes and the endoplasmic reticulum also play important roles in the process. A number of different stimuli were found to directly or indirectly target the lysosomal membrane, thereby inducing lysosomal permeabilization and the release of cysteine cathepsins and the aspartic protease cathepsin D into the cytosol. Once in the cytosol, cathepsins can trigger cell death by different mechanisms. Here we discuss the different signaling pathways used by lysosomal proteases to trigger apoptosis and their potential role in physiological processes. |
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Authors:
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Veronika Stoka; Vito Turk; Boris Turk |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biological chemistry Volume: 388 ISSN: 1431-6730 ISO Abbreviation: Biol. Chem. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-07 Completed Date: 2007-10-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9700112 Medline TA: Biol Chem Country: Germany |
Other Details:
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Languages: eng Pagination: 555-60 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, J. Stefan Institute, SI-1000 Ljubljana, Slovenia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Cathepsins / metabolism* Cysteine Humans Lysosomes / metabolism Signal Transduction |
| Chemical | |
Reg. No./Substance:
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52-90-4/Cysteine; EC 3.4.-/Cathepsins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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