Document Detail

Lysophosphatidic acid synthesis and release.
MedLine Citation:
PMID:  11324699     Owner:  NLM     Status:  MEDLINE    
Lysophosphatidic acid (LPA) is a bioactive phospholipid controlling numerous cellular responses through the activation of specific G-protein coupled transmembrane receptors. LPA is present in several biological fluids (serum, plasma, aqueous humor) and can be secreted by several cell types (platelets, fibroblasts, adipocytes, cancer cells). Whereas, multiple pathways of synthesis and degradation of LPA have been described, their relative contribution in extracellular secretion and biodisponibility is still a matter of debate. The first part of the present review is devoted to the description of the different enzymes involved in LPA synthesis (acyltransferases, phospholipases, kinases) and degradation (lysophospholipases, lipid-phosphatases), as well as to the molecules involved in LPA transport (albumin, fatty acid binding proteins, gelsolin, lipoproteins). In a second part, the different physio-pathological situations (aggregation, cancer, injuries) associated with LPA production, as well as the potential role played by LPA in genesis of certain diseases (cancer, obesity, arteriosclerosis) are listed and analyzed.
C Pagès; M F Simon; P Valet; J S Saulnier-Blache
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prostaglandins & other lipid mediators     Volume:  64     ISSN:  1098-8823     ISO Abbreviation:  Prostaglandins Other Lipid Mediat.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-27     Completed Date:  2001-09-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9808648     Medline TA:  Prostaglandins Other Lipid Mediat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
INSERM U317, Institut Louis Bugnard, Université Paul Sabatier, CHU Rangueil, Toulouse, France.
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MeSH Terms
Adipose Tissue / growth & development
Arteriosclerosis / metabolism
Biological Transport
Lysophospholipids / metabolism*
Models, Biological
Neoplasms / metabolism
Phosphatidic Acids / metabolism
Platelet Aggregation
Reg. No./Substance:
0/Lysophospholipids; 0/Phosphatidic Acids

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