Document Detail

Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases.
MedLine Citation:
PMID:  15271294     Owner:  NLM     Status:  MEDLINE    
The biological actions of the lysolipid agonists sphingosine 1-phosphate and lysophosphatidic acid, in addition to other bioactive lipid phosphates such as phosphatidic acid and ceramide 1-phosphate, can be influenced by a family of lipid phosphate phosphatases (LPP), including LPP1, LPP2, LPP3, the Drosophila homologues Wunen (Wun) and Wunen2 (Wun2) and sphingosine 1-phosphate phosphatases 1 and 2 (SPP1, SPP2). This review describes the characteristic of these enzymes and their potential physiological roles in regulating intracellular and extracellular actions and amounts of these lipids in addition to the involvement of these phosphatases in development.
Susan Pyne; Kok-Choi Kong; Peter I Darroch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  15     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-07-23     Completed Date:  2005-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  491-501     Citation Subset:  IM    
Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Research, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, Scotland, UK.
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MeSH Terms
Lysophospholipids / metabolism*
Membrane Proteins / metabolism*
Phosphatidate Phosphatase / metabolism*
Phosphoric Monoester Hydrolases / metabolism*
Protein Structure, Tertiary
Receptors, G-Protein-Coupled / metabolism
Sphingosine / analogs & derivatives*,  metabolism*
Reg. No./Substance:
0/Lysophospholipids; 0/Membrane Proteins; 0/Receptors, G-Protein-Coupled; 123-78-4/Sphingosine; 22002-87-5/lysophosphatidic acid; 26993-30-6/sphingosine 1-phosphate; EC 3.1.3.-/Phosphoric Monoester Hydrolases; EC 3.1.3.-/SGPP1 protein, human; EC 3.1.3.-/lipid phosphate phosphatase; EC 3.1.3.-/sphingosine-1-phosphate phosphatase; EC Phosphatase

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