Document Detail


Lysophosphatidic acid in atherosclerotic diseases.
MedLine Citation:
PMID:  22568609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lysophosphatidic acid (LPA) is a potent bioactive phospholipid. As many other biological active lipids, LPA is an autacoid: it is formed locally on demand, and it acts locally near its site of synthesis. LPA has a plethora of biological activities on blood cells (platelets, monocytes) and cells of the vessel wall (endothelial cells, smooth muscle cells, macrophages) that are all key players in atherosclerotic and atherothrombotic processes. The specific cellular actions of LPA are determined by its multifaceted molecular structures, the expression of multiple G-protein coupled LPA receptors at the cell surface and their diverse coupling to intracellular signalling pathways. Numerous studies have now shown that LPA has thrombogenic and atherogenic actions. Here, we aim to provide a comprehensive, yet concise, thoughtful and critical review of this exciting research area and to pinpoint potential pharmacological targets for inhibiting thrombogenic and atherogenic activities of LPA. We hope that the review will serve to accelerate knowledge of basic and clinical science, and to foster drug development in the field of LPA and atherosclerotic/atherothrombotic diseases.
Authors:
Andreas Schober; Wolfgang Siess
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  British journal of pharmacology     Volume:  167     ISSN:  1476-5381     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-05     Completed Date:  2013-01-17     Revised Date:  2013-10-11    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  465-82     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society.
Affiliation:
Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atherosclerosis / drug therapy,  physiopathology*
Drug Design
Humans
Lysophospholipids / metabolism*
Signal Transduction
Thrombosis / drug therapy,  etiology,  physiopathology*
Chemical
Reg. No./Substance:
0/Lysophospholipids; 22002-87-5/lysophosphatidic acid
Comments/Corrections

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