| Lysophosphatidic Acid Action in the Bovine Corpus Luteum-An In Vitro Study. | |
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MedLine Citation:
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PMID: 22972186 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We examined whether the CL is a site for lysophosphatidic acid (LPA) synthesis and/or a target for LPA action in the bovine reproductive tract. LPA concentrations in the CL tissue increased towards the end of the cycle and were stable during early pregnancy. No changes in the expression of LPA receptors (LPARs) occurred during the estrous cycle. The expressions of LPAR2 and LPAR4 on days 17-19 of pregnancy were higher than those on the respective days of the estrous cycle and higher than those on days 8-10 of pregnancy. LPA stimulated P4 synthesis via 3βHSD stimulation but did not modulate the interferon-tau (IFNτ) influence on P4 synthesis in steroidogenic cells. Moreover, we found LPA-dependent stimulation of IFNτ action on 2,5'-oligoadenylate synthase (OAS1) and ubiquitin-like IFN-stimulated gene 15-kDa protein (ISG15) expression. The present study demonstrated that the CL might be a site of LPA synthesis and target of LPA action in the bovine reproductive tract. We postulate that during the estrous cycle and early pregnancy, LPA exerts autocrine and paracrine effects on the CL mainly via LPAR2 and LPAR4. The stimulatory effect of LPA on P4 synthesis via 3βHSD stimulation and LPA-dependent stimulation of IFNτ action on OAS1 and ISG15 expression suggest that LPA is an additional auxiliary luteosupportive factor in steroidogenic cells. |
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Authors:
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Ilona Kowalczyk-Zieba; Dorota Boruszewska; Jean Sebastian Saulnier-Blache; Luis Lopes DA Costa; Katarzyna Jankowska; Dariusz Jan Skarzynski; Izabela Woclawek-Potocka |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-24 |
Journal Detail:
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Title: The Journal of reproduction and development Volume: - ISSN: 1348-4400 ISO Abbreviation: J. Reprod. Dev. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-9-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9438792 Medline TA: J Reprod Dev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Reproductive Immunology and Pathology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-747 Olsztyn, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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