Document Detail


Lysolecithin affects the viscosity, permeability, and peptic susceptibility of gastric mucin.
MedLine Citation:
PMID:  3810007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of lysolecithin and lecithin on gastric mucin viscosity, permeability to hydrogen ion, and degradation by pepsin was investigated. Preincubation with lysolecithin produced a marked decrease in the glycoprotein viscosity. This decrease was concentration-dependent and at 10 mM lysolecithin reached a value of 74%. A 25% increase in mucin viscosity was obtained with 10 mM lecithin. Permeability measurements showed that 10 mM lecithin increased the retardation ability of the glycoprotein to hydrogen ion by 11%, whereas a 12% decrease in the retardation capacity of the glycoprotein was obtained with 10 mM lysolecithin. The results of peptic activity assay indicated that whereas lecithin had no effect on the rate of mucin proteolysis, the lysolecithin exerted significant (75%) stimulatory effect. The results suggest that lysolecithin in the stomach weakens the integrity of the protective mucus layer by promoting peptic degradation, reducing the ability to resist acid penetration, and decreasing viscosity of its mucin component.
Authors:
B L Slomiany; J Sarosiek; Y H Liau; W Laszewicz; A Slomiany
Related Documents :
1653657 - Haemolytic effects of exercise.
17283397 - Fluid and electrolyte shifts during and after agility competitions in dogs.
25271307 - Voluntary aerobic exercise reverses frailty in old mice.
9043917 - Endometrial perfusion across the normal human menstrual cycle assessed by laser doppler...
12766377 - Smoking cessation, smoking reduction, and delayed quitting among smokers given nicotine...
18703757 - Effect of eccentric exercise-induced muscle damage on the dynamics of muscle oxygenatio...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  21     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-03-10     Completed Date:  1987-03-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1073-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane Permeability / drug effects
Gastric Mucosa / metabolism*
Lysophosphatidylcholines / pharmacology*
Mucins / analysis,  metabolism*
Phosphatidylcholines / pharmacology*
Swine
Viscosity
Grant Support
ID/Acronym/Agency:
AM 21684-08/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Lysophosphatidylcholines; 0/Mucins; 0/Phosphatidylcholines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of vagal stimulation on the release of cholecystokinin in anaesthetized pigs.
Next Document:  The age-, sex-, and site-specific occurrence of adenomas and carcinomas of the large intestine withi...